NRP1

NRP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1KEX, 2QQI, 2QQM, 2QQN, 3I97, 4DEQ, 4RN5, 5C7G
Dynodwyr
Cyfenwau	NRP1, BDCA4, CD304, NP1, NRP, VEGF165R, Neuropilin 1
Dynodwyr allanol	OMIM: 602069 HomoloGene: 2876 GeneCards: NRP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • heparin binding • vascular endothelial growth factor binding • GO:0019974 cytokine binding • semaphorin receptor activity • coreceptor activity • metal ion binding • vascular endothelial growth factor-activated receptor activity • growth factor binding • GO:0001948, GO:0016582 protein binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • protein kinase binding Cydrannau o'r gell • cytosol • bilen • extracellular region • semaphorin receptor complex • cell surface • sorting endosome • integral component of membrane • growth cone • receptor complex • Cellbilen • axon • neuronal cell body • early endosome • neurofilament • GO:0016023 cytoplasmic vesicle • extracellular space • focal adhesion • neuron projection • glutamatergic synapse • integral component of postsynaptic membrane Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • facioacoustic ganglion development • vascular endothelial growth factor signaling pathway • VEGF-activated neuropilin signaling pathway involved in axon guidance • toxin transport • cell migration involved in sprouting angiogenesis • semaphorin-plexin signaling pathway involved in axon guidance • positive regulation of retinal ganglion cell axon guidance • positive regulation of smooth muscle cell migration • sympathetic neuron projection guidance • vascular endothelial growth factor receptor signaling pathway • sensory neuron axon guidance • angiogenesis • positive regulation of ERK1 and ERK2 cascade • animal organ morphogenesis • protein localization to early endosome • trigeminal nerve structural organization • regulation of axon extension involved in axon guidance • coronary artery morphogenesis • negative regulation of extrinsic apoptotic signaling pathway • neuron development • trigeminal nerve morphogenesis • angiogenesis involved in coronary vascular morphogenesis • commissural neuron axon guidance • negative regulation of axon extension involved in axon guidance • heart development • response to wounding • artery morphogenesis • positive regulation of peptidyl-tyrosine phosphorylation • branching involved in blood vessel morphogenesis • platelet-derived growth factor receptor signaling pathway • positive chemotaxis • facial nerve structural organization • hepatocyte growth factor receptor signaling pathway • axonal fasciculation • retina vasculature morphogenesis in camera-type eye • dorsal root ganglion morphogenesis • axon extension involved in axon guidance • sympathetic ganglion development • cell differentiation • semaphorin-plexin signaling pathway involved in neuron projection guidance • cellular response to hepatocyte growth factor stimulus • dendrite development • sprouting angiogenesis • neuron migration • nervous system development • regulation of retinal ganglion cell axon guidance • branchiomotor neuron axon guidance • gonadotrophin-releasing hormone neuronal migration to the hypothalamus • negative regulation of axon extension • retinal ganglion cell axon guidance • renal artery morphogenesis • ventral trunk neural crest cell migration • positive regulation of endothelial cell proliferation • sympathetic nervous system development • endothelial tip cell fate specification • cell-cell signaling • regulation of vesicle-mediated transport • trigeminal ganglion development • positive regulation of cytokine activity • positive regulation of axon extension involved in axon guidance • axon guidance • vestibulocochlear nerve structural organization • multicellular organism development • neural crest cell migration involved in autonomic nervous system development • endothelial cell chemotaxis • axonogenesis involved in innervation • dichotomous subdivision of terminal units involved in salivary gland branching • cellular response to vascular endothelial growth factor stimulus • motor neuron axon guidance • nerve development • cell migration • sympathetic neuron projection extension • semaphorin-plexin signaling pathway • GO:0072468 signal transduction • otic placode development • motor neuron migration • outflow tract septum morphogenesis • substrate-dependent cell migration, cell extension • integrin-mediated signaling pathway • positive regulation of endothelial cell migration • actin cytoskeleton reorganization • regulation of Cdc42 protein signal transduction • substrate adhesion-dependent cell spreading • neuropilin signaling pathway • VEGF-activated neuropilin signaling pathway • positive regulation of phosphorylation • endothelial cell migration • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • positive regulation of angiogenesis • positive regulation of filopodium assembly • positive regulation of stress fiber assembly • positive regulation of focal adhesion assembly • positive regulation of cell migration involved in sprouting angiogenesis • positive regulation of substrate adhesion-dependent cell spreading • positive regulation of actin cytoskeleton reorganization • postsynapse organization • basal dendrite development • basal dendrite arborization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8829	n/a
Ensembl	ENSG00000099250	n/a
UniProt	O14786	n/a
RefSeq (mRNA)	NM_001024628 NM_001024629 NM_001244972 NM_001244973 NM_003873 NM_001330068	n/a
RefSeq (protein)	NP_001019799 NP_001019800 NP_001231901 NP_001231902 NP_001316997 NP_003864	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NRP1 yw NRP1 a elwir hefyd yn Neuropilin-1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10p11.22.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NRP1.

• NP1
• NRP
• BDCA4
• CD304
• VEGF165R

Llyfryddiaeth

• "Curcumin-loaded nanoliposomes linked to homing peptides for integrin targeting and neuropilin-1-mediated internalization. ". Pharm Biol. 2017. PMID 27937055.
• "A Novel Physiological Glycosaminoglycan-Deficient Splice Variant of Neuropilin-1 Is Anti-Tumorigenic In Vitro and In Vivo. ". PLoS One. 2016. PMID 27798666.
• "Neuropilin-1 modulates TGFβ signaling to drive glioblastoma growth and recurrence after anti-angiogenic therapy. ". PLoS One. 2017. PMID 28938007.
• "Neuropilin 1 binds PDGF-D and is a co-receptor in PDGF-D-PDGFRβ signaling. ". J Cell Sci. 2017. PMID 28254885.
• "Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality.". Oncogene. 2017. PMID 28092670.