NR4A1

NR4A1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2QW4, 3V3E, 3V3Q, 4JGV, 4KZI, 4KZJ, 4KZM, 4RZE, 4RZF, 4RZG, 4RE8, 4REE, 4REF, 4WHF, 4WHG
Dynodwyr
Cyfenwau	NR4A1, GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3, nuclear receptor subfamily 4 group A member 1, NH41
Dynodwyr allanol	OMIM: 139139 HomoloGene: 1612 GeneCards: NR4A1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • metal ion binding • steroid hormone receptor activity • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • glucocorticoid receptor binding Cydrannau o'r gell • nuclear membrane • nucleoplasm • cnewyllyn cell • cytoplasm • cytosol • transcription regulator complex Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • positive regulation of endothelial cell proliferation • negative regulation of cell cycle • cellular response to fibroblast growth factor stimulus • transcription, DNA-templated • cell migration involved in sprouting angiogenesis • endothelial cell chemotaxis • cellular response to corticotropin-releasing hormone stimulus • cellular response to vascular endothelial growth factor stimulus • transcription initiation from RNA polymerase II promoter • fat cell differentiation • regulation of type B pancreatic cell proliferation • GO:0072468 signal transduction • steroid hormone mediated signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • intracellular receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3164	n/a
Ensembl	ENSG00000123358	n/a
UniProt	P22736	n/a
RefSeq (mRNA)	NM_001202233 NM_001202234 NM_002135 NM_173157 NM_173158	n/a
RefSeq (protein)	NP_001189162 NP_001189163 NP_002126 NP_775180 NP_002126.2 NP_775180.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NR4A1 yw NR4A1 a elwir hefyd yn Nuclear receptor subfamily 4, group A, member 1, isoform CRA_d a Nuclear receptor subfamily 4 group A member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q13.13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NR4A1.

• HMR
• N10
• TR3
• NP10
• GFRP1
• NAK-1
• NGFIB
• NUR77

Llyfryddiaeth

• "Inactivation of the orphan nuclear receptor NR4A1 contributes to apoptosis induction by fangchinoline in pancreatic cancer cells. ". Toxicol Appl Pharmacol. 2017. PMID 28754437.
• "Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells. ". J Immunol. 2017. PMID 27940659.
• "PAX3-FOXO1A Expression in Rhabdomyosarcoma Is Driven by the Targetable Nuclear Receptor NR4A1. ". Cancer Res. 2017. PMID 27864345.
• "Nuclear receptor 4A1 (NR4A1) as a drug target for treating rhabdomyosarcoma (RMS). ". Oncotarget. 2016. PMID 27144436.
• "Nur77 gene expression levels were involved in different ACTH-secretion autonomy between Cushing's disease and subclinical Cushing's disease.". Endocr J. 2016. PMID 27025408.