NR1I3

NR1I3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1XVP, 1XV9
Dynodwyr
Cyfenwau	NR1I3, CAR, CAR1, MB67, nuclear receptor subfamily 1 group I member 3
Dynodwyr allanol	OMIM: 603881 HomoloGene: 3759 GeneCards: NR1I3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001105 transcription coactivator activity • zinc ion binding • metal ion binding • steroid hormone receptor activity • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000975 transcription cis-regulatory region binding • transcription factor binding • nuclear receptor coactivator activity • signaling receptor activity Cydrannau o'r gell • cytoplasm • cytosol • nucleoplasm • Cytosgerbwd • cnewyllyn cell • RNA polymerase II transcription regulator complex Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • transcription initiation from RNA polymerase II promoter • GO:0045996 negative regulation of transcription, DNA-templated • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • steroid hormone mediated signaling pathway • androgen receptor signaling pathway • intracellular receptor signaling pathway • multicellular organism development • cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9970	n/a
Ensembl	ENSG00000143257	n/a
UniProt	Q14994 Q6GZ81	n/a
RefSeq (mRNA)	NM_001077469 NM_001077470 NM_001077471 NM_001077472 NM_001077473 NM_001077474 NM_001077475 NM_001077476 NM_001077477 NM_001077478 NM_001077479 NM_001077480 NM_001077481 NM_001077482 NM_005122	n/a
RefSeq (protein)	NP_001070937 NP_001070938 NP_001070939 NP_001070940 NP_001070941 NP_001070942 NP_001070943 NP_001070944 NP_001070945 NP_001070946 NP_001070947 NP_001070948 NP_001070949 NP_001070950 NP_005113	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NR1I3 yw NR1I3 a elwir hefyd yn Constitutive androstane receptor SV10 a Nuclear receptor subfamily 1 group I member 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NR1I3.

• CAR
• CAR1
• MB67

Llyfryddiaeth

• "Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cells. ". Biochem Pharmacol. 2015. PMID 26275810.
• "High resolution melting analysis of the NR1I3 genetic variants: Is there an association with neonatal hyperbilirubinemia?". Gene. 2015. PMID 26188155.
• "Correlates of efavirenz exposure in Chilean patients affected with human immunodeficiency virus reveals a novel association with a polymorphism in the constitutive androstane receptor. ". Ther Drug Monit. 2013. PMID 23172109.
• "[Expression and clinical significance of constitutive androstane receptor in placental syntrophoblast of intrahepatic cholestasis of pregnancy]. ". Zhonghua Fu Chan Ke Za Zhi. 2011. PMID 21733368.
• "Expression of CAR in SW480 and HepG2 cells during G1 is associated with cell proliferation.". Biochem Biophys Res Commun. 2008. PMID 18331826.