NR1I2

NR1I2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ILG, 1ILH, 1M13, 1NRL, 1SKX, 2O9I, 2QNV, 3CTB, 3HVL, 3R8D, 4J5W, 4J5X, 4NY9, 4S0S, 4S0T, 4XHD, 4X1F, 4X1G, 4XAO, 5A86
Dynodwyr
Cyfenwau	NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR, nuclear receptor subfamily 1 group I member 2
Dynodwyr allanol	OMIM: 603065 HomoloGene: 40757 GeneCards: NR1I2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001105 transcription coactivator activity • zinc ion binding • metal ion binding • steroid hormone receptor activity • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000975 transcription cis-regulatory region binding • transcription factor binding • nuclear receptor coactivator activity • signaling receptor activity Cydrannau o'r gell • cnewyllyn cell • nucleoplasm • nuclear body • intermediate filament cytoskeleton • RNA polymerase II transcription regulator complex Prosesau biolegol • steroid metabolic process • GO:0009373 regulation of transcription, DNA-templated • xenobiotic transport • xenobiotic export • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:1901313 positive regulation of gene expression • xenobiotic metabolic process • transcription initiation from RNA polymerase II promoter • GO:0045996 negative regulation of transcription, DNA-templated • GO:0072468 signal transduction • steroid hormone mediated signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • intracellular receptor signaling pathway • multicellular organism development • cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8856	n/a
Ensembl	ENSG00000144852	n/a
UniProt	O75469	n/a
RefSeq (mRNA)	NM_033013 NM_003889 NM_022002	n/a
RefSeq (protein)	NP_003880 NP_071285 NP_148934	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NR1I2 yw NR1I2 a elwir hefyd yn Nuclear receptor subfamily 1 group I member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3q13.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NR1I2.

• BXR
• PAR
• PRR
• PXR
• SAR
• SXR
• ONR1
• PAR1
• PAR2
• PARq

Llyfryddiaeth

• "TR47, a PAR1-based peptide, inhibits melanoma cell migration in vitro and metastasis in vivo. ". Biochem Biophys Res Commun. 2018. PMID 29196264.
• "Association of NR1I2 gene polymorphisms and time of progression to AIDS. ". Mem Inst Oswaldo Cruz. 2017. PMID 28327790.
• "Influence of a critical single nucleotide polymorphism on nuclear receptor PXR-promoter function. ". Cell Biol Int. 2017. PMID 28198586.
• "Effect of Pregnane X Receptor*1B genetic polymorphisms on postoperative analgesia with fentanyl in Chinese patients undergoing gynecological surgery. ". BMC Med Genet. 2016. PMID 27876007.
• "66034T/C polymorphism of the human pregnane X receptor (hPXR) as potential risk factor for drug resistance in epilepsy - Preliminary study.". Neurol Neurochir Pol. 2017. PMID 27836114.