NR1H3 Dynodwyr Cyfenwau NR1H3 Dynodwyr allanol OMIM: 602423 HomoloGene: 21165 GeneCards: NR1H3 Ontoleg y genyn Gweithrediad moleciwlaidd • cholesterol binding • GO:0001948, GO:0016582 protein binding • zinc ion binding • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • sterol response element binding • steroid hormone receptor activity • DNA binding • sequence-specific DNA binding • metal ion binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001105 transcription coactivator activity • GO:0000975 transcription cis-regulatory region binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • transcription factor binding • nuclear receptor coactivator activity • signaling receptor activity Cydrannau o'r gell • receptor complex • nucleoplasm • RNA polymerase II transcription regulator complex • cnewyllyn cell • cytoplasm Prosesau biolegol • positive regulation of toll-like receptor 4 signaling pathway • sterol homeostasis • negative regulation of pancreatic juice secretion • negative regulation of inflammatory response • cellular response to lipopolysaccharide • negative regulation of lipid transport • positive regulation of lipoprotein lipase activity • lipid homeostasis • triglyceride homeostasis • negative regulation of macrophage activation • negative regulation of macrophage derived foam cell differentiation • positive regulation of cholesterol transport • negative regulation of cholesterol storage • GO:0009373 regulation of transcription, DNA-templated • positive regulation of triglyceride biosynthetic process • positive regulation of cholesterol efflux • GO:0051247, GO:0051200 positive regulation of protein metabolic process • negative regulation of interferon-gamma-mediated signaling pathway • regulation of circadian rhythm • transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • response to progesterone • steroid hormone mediated signaling pathway • apoptotic cell clearance • positive regulation of fatty acid biosynthetic process • transcription initiation from RNA polymerase II promoter • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of secretion of lysosomal enzymes • negative regulation of pinocytosis • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • intracellular receptor signaling pathway • cholesterol homeostasis • lipid metabolism • multicellular organism development • cell differentiation • negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn NR1H3 yw NR1H3 a elwir hefyd yn Liver X nuclear receptor alpha variant 1 ac Oxysterols receptor LXR-alpha (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11p11.2.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NR1H3.
"Platelet-activating factor and hydrogen peroxide exert a dual modulatory effect on the transcription of LXRα and its target genes in human neutrophils. ". Int Immunopharmacol . 2016. PMID 27351826 . "Nuclear Receptor NR1H3 in Familial Multiple Sclerosis. ". Neuron . 2016. PMID 27253448 . "Liver X receptor α (LXRα) promoted invasion and EMT of gastric cancer cells by regulation of NF-κB activity. ". Hum Cell . 2017. PMID 28091828 . "Fatty acid binding profile of the liver X receptor α. ". J Lipid Res . 2017. PMID 28011707 . "Effects of platycodin D on IL-1β-induced inflammatory response in human osteoarthritis chondrocytes. ". Int Immunopharmacol . 2016. PMID 27743553 . 
