NR1H2

NR1H2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1P8D, 1PQ6, 1PQ9, 1PQC, 1UPV, 1UPW, 3KFC, 3L0E, 4DK7, 4DK8, 4RAK, 5HJP, 4NQA, 5I4V,%%s4NQA
Dynodwyr
Cyfenwau	NR1H2, LXR-b, LXRB, NER, NER-I, RIP15, UNR, Liver X receptor beta, nuclear receptor subfamily 1 group H member 2
Dynodwyr allanol	OMIM: 600380 HomoloGene: 21397 GeneCards: NR1H2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • ATPase binding • zinc ion binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • metal ion binding • retinoid X receptor binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • steroid hormone receptor activity • apolipoprotein A-I receptor binding • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000975 transcription cis-regulatory region binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • transcription factor binding • nuclear receptor coactivator activity • signaling receptor activity Cydrannau o'r gell • cytoplasm • nucleoplasm • cnewyllyn cell • RNA polymerase II transcription regulator complex Prosesau biolegol • positive regulation of high-density lipoprotein particle assembly • negative regulation of proteolysis • positive regulation of triglyceride biosynthetic process • GO:0051247, GO:0051200 positive regulation of protein metabolic process • negative regulation of interferon-gamma-mediated signaling pathway • positive regulation of cholesterol transport • GO:0009373 regulation of transcription, DNA-templated • cellular lipid metabolic process • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • positive regulation of secretion of lysosomal enzymes • positive regulation of lipid storage • positive regulation of lipoprotein lipase activity • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of fatty acid biosynthetic process • negative regulation of gene expression • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of cholesterol storage • negative regulation of pinocytosis • GO:1901313 positive regulation of gene expression • retinoic acid receptor signaling pathway • positive regulation of cholesterol efflux • positive regulation of pancreatic juice secretion • lipid homeostasis • negative regulation of lipid transport • transcription initiation from RNA polymerase II promoter • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of macrophage derived foam cell differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • steroid hormone mediated signaling pathway • cholesterol homeostasis • lipid metabolism • multicellular organism development • cell differentiation • cellular response to lipopolysaccharide • negative regulation of cold-induced thermogenesis • intracellular receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7376	n/a
Ensembl	ENSG00000131408	n/a
UniProt	P55055	n/a
RefSeq (mRNA)	NM_007121 NM_001256647	n/a
RefSeq (protein)	NP_001243576 NP_009052 NP_009052.3	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NR1H2 yw NR1H2 a elwir hefyd yn Oxysterols receptor LXR-beta a Liver X nuclear receptor beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NR1H2.

• NER
• UNR
• LXRB
• LXR-b
• NER-I
• RIP15

Llyfryddiaeth

• "Liver X receptor ligand cytotoxicity in colon cancer cells and not in normal colon epithelial cells depends on LXRβ subcellular localization. ". Oncotarget. 2015. PMID 26450852.
• "Destabilization of the torsioned conformation of a ligand side chain inverts the LXRβ activity. ". Biochim Biophys Acta. 2015. PMID 26434697.
• "Liver X Receptor (LXR)-regulated Genes of Cholesterol Trafficking and Breast Cancer Severity. ". Anticancer Res. 2017. PMID 28982861.
• "Interactions among polymorphisms of NER genes prompt the risk of transplantation rejection. ". Yi Chuan. 2017. PMID 28115302.
• "Down-Regulated Expression of Liver X Receptor beta in Cortical Lesions of Patients with Focal Cortical Dysplasia.". J Mol Neurosci. 2016. PMID 27437943.