NOTCH2

NOTCH2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2OO4
Dynodwyr
Cyfenwau	NOTCH2, AGS2, HJCYS, hN2, Notch-2, notch 2, notch receptor 2
Dynodwyr allanol	OMIM: 600275 HomoloGene: 7865 GeneCards: NOTCH2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • GO:0001948, GO:0016582 protein binding • signaling receptor activity Cydrannau o'r gell • cytoplasm • integral component of membrane • endoplasmic reticulum membrane • bilen • Golgi membrane • receptor complex • Cellbilen • integral component of plasma membrane • nucleoplasm • extracellular region • cell surface • cnewyllyn cell Prosesau biolegol • Notch signaling pathway • cell differentiation • hemopoiesis • pulmonary valve morphogenesis • GO:0009373 regulation of transcription, DNA-templated • positive regulation of Ras protein signal transduction • negative regulation of apoptotic process • marginal zone B cell differentiation • transcription, DNA-templated • nervous system development • stem cell population maintenance • multicellular organism development • atrial septum morphogenesis • GO:0090343, GO:0090342 regulation of developmental process • bone remodeling • animal organ morphogenesis • transcription initiation from RNA polymerase II promoter • Notch signaling involved in heart development • GO:0097285 apoptotic process • cell fate determination • intracellular receptor signaling pathway • negative regulation of gene expression • negative regulation of growth rate • positive regulation of ERK1 and ERK2 cascade • regulation of osteoclast development • positive regulation of keratinocyte proliferation • regulation of actin cytoskeleton reorganization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4853	n/a
Ensembl	ENSG00000134250	n/a
UniProt	Q04721	n/a
RefSeq (mRNA)	NM_001200001 NM_024408	n/a
RefSeq (protein)	NP_001186930 NP_077719	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NOTCH2 yw NOTCH2 a elwir hefyd yn Notch 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NOTCH2.

• hN2
• AGS2
• HJCYS

Llyfryddiaeth

• "An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD. ". Blood. 2017. PMID 28851699.
• "Notch2 is a crucial regulator of self-renewal and tumorigenicity in human hepatocellular carcinoma cells. ". Oncol Rep. 2016. PMID 27221981.
• "Notch2 signaling contributes to cell growth, invasion, and migration in salivary adenoid cystic carcinoma. ". Mol Cell Biochem. 2016. PMID 26427670.
• "NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells. ". Oncol Rep. 2015. PMID 26252838.
• "A novel NOTCH2 mutation identified in a Korean family with Hajdu-Cheney syndrome showing phenotypic diversity.". Ann Clin Lab Sci. 2015. PMID 25696021.