NOS2

NOS2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1NSI, 2LL6, 2NSI, 3E7G, 3EJ8, 3HR4, 4CX7, 4NOS
Dynodwyr
Cyfenwau	NOS2, HEP-NOS, INOS, NOS, NOS2A, Nitric oxide synthase 2
Dynodwyr allanol	OMIM: 163730 HomoloGene: 55473 GeneCards: NOS2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • FMN binding • protein homodimerization activity • flavin adenine dinucleotide binding • arginine binding • tetrahydrobiopterin binding • metal ion binding • calmodulin binding • GO:0001948, GO:0016582 protein binding • heme binding • oxidoreductase activity • signaling receptor binding • nitric-oxide synthase activity • NADPH-hemoprotein reductase activity • NADP binding Cydrannau o'r gell • cytoplasm • cytosol • cortical cytoskeleton • peroxisome • intracellular anatomical structure • perinuclear region of cytoplasm • cnewyllyn cell • peroxisomal matrix • Cellbilen • vesicle membrane Prosesau biolegol • positive regulation of guanylate cyclase activity • response to hypoxia • nitric oxide biosynthetic process • positive regulation of leukocyte mediated cytotoxicity • response to bacterium • GO:1903363 negative regulation of protein catabolic process • regulation of insulin secretion • negative regulation of blood pressure • regulation of cytokine production involved in inflammatory response • positive regulation of killing of cells of other organism • negative regulation of gene expression • cell redox homeostasis • arginine catabolic process • prostaglandin secretion • response to lipopolysaccharide • innate immune response in mucosa • regulation of cell population proliferation • peptidyl-cysteine S-nitrosylation • defense response to bacterium • Rhythm circadaidd • GO:0051636 defense response to Gram-negative bacterium • nitric oxide mediated signal transduction • cellular response to interferon-gamma • regulation of cellular respiration • cellular response to lipopolysaccharide • superoxide metabolic process • cytokine-mediated signaling pathway • protein targeting to peroxisome • response to hormone Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4843	n/a
Ensembl	ENSG00000007171	n/a
UniProt	P35228	n/a
RefSeq (mRNA)	NM_000625 NM_153292	n/a
RefSeq (protein)	NP_000616	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NOS2 yw NOS2 a elwir hefyd yn Nitric oxide synthase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NOS2.

• NOS
• INOS
• NOS2A
• HEP-NOS

Llyfryddiaeth

• "Silver nanoparticles can attenuate nitrative stress. ". Redox Biol. 2017. PMID 28157664.
• "The association between chronic pancreatitis and the iNOS-2087A>G polymorphism. ". Rom J Intern Med. 2017. PMID 28125406.
• "Identifying the Long-Term Role of Inducible Nitric Oxide Synthase after Contusive Spinal Cord Injury Using a Transgenic Mouse Model. ". Int J Mol Sci. 2017. PMID 28125047.
• "Immunohistochemical characterization of early and advanced knee osteoarthritis by NF-κB and iNOS expression. ". J Orthop Res. 2017. PMID 27958655.
• "Enhanced aggressiveness of bystander cells in an anti-tumor photodynamic therapy model: Role of nitric oxide produced by targeted cells.". Free Radic Biol Med. 2017. PMID 27884704.