NOD1

NOD1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2B1W, 2DBD, 2NSN, 2NZ7, 4E9M, 4JQW
Dynodwyr
Cyfenwau	NOD1, CARD4, CLR7.1, NLRC1, nucleotide binding oligomerization domain containing 1
Dynodwyr allanol	OMIM: 605980 HomoloGene: 4440 GeneCards: NOD1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • protein homodimerization activity • GO:0001948, GO:0016582 protein binding • peptidoglycan binding • identical protein binding • cysteine-type endopeptidase activator activity involved in apoptotic process • CARD domain binding • ATP binding • GO:0032403 protein-containing complex binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • Cellbilen • basolateral plasma membrane • apical plasma membrane Prosesau biolegol • regulation of apoptotic process • defense response • detection of biotic stimulus • GO:0007243 intracellular signal transduction • positive regulation of cell death • immune system process • positive regulation of JNK cascade • positive regulation of xenophagy • positive regulation of NIK/NF-kappaB signaling • cellular response to muramyl dipeptide • JNK cascade • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of dendritic cell antigen processing and presentation • positive regulation of nitric-oxide synthase activity • defense response to bacterium • positive regulation of NF-kappaB transcription factor activity • protein complex oligomerization • detection of bacterium • positive regulation of interleukin-1 beta production • positive regulation of ERK1 and ERK2 cascade • positive regulation of interleukin-6 production • positive regulation of tumor necrosis factor production • positive regulation of I-kappaB kinase/NF-kappaB signaling • inflammatory response • activation of cysteine-type endopeptidase activity involved in apoptotic process • nucleotide-binding oligomerization domain containing signaling pathway • GO:0072468 signal transduction • positive regulation of stress-activated MAPK cascade • GO:0051637 defense response to Gram-positive bacterium • GO:0097285 apoptotic process • innate immune response • interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10392	n/a
Ensembl	ENSG00000106100	n/a
UniProt	Q9Y239	n/a
RefSeq (mRNA)	NM_006092 NM_001354849	n/a
RefSeq (protein)	NP_006083 NP_001341778	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NOD1 yw NOD1 a elwir hefyd yn Nucleotide binding oligomerization domain containing 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7p14.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NOD1.

• CARD4
• NLRC1
• CLR7.1

Llyfryddiaeth

• "NOD1 in contrast to NOD2 functional polymorphism influence Chlamydia trachomatis infection and the risk of tubal factor infertility. ". Pathog Dis. 2015. PMID 25854006.
• "The intracellular location, mechanisms and outcomes of NOD1 signaling. ". Cytokine. 2015. PMID 25801093.
• "NOD1 and NOD2: Beyond Peptidoglycan Sensing. ". Trends Immunol. 2017. PMID 28823510.
• "Rare Variants in NOD1 Associated with Carotid Bifurcation Intima-Media Thickness in Dominican Republic Families. ". PLoS One. 2016. PMID 27936005.
• "Increased NOD1, but not NOD2, activity in subcutaneous adipose tissue from patients with metabolic syndrome.". Obesity (Silver Spring). 2015. PMID 26052894.