NKX2-1

NKX2-1
Dynodwyr
Cyfenwau	NKX2-1, Nkx2-1, AV026640, Nkx2.1, T/EBP, Titf1, Ttf-1, BCH, BHC, NK-2, NKX2A, TEBP, TTF1, NMTC1, NK2 homeobox 1
Dynodwyr allanol	OMIM: 600635 HomoloGene: 2488 GeneCards: NKX2-1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • enzyme binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • intronic transcription regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding Cydrannau o'r gell • nucleoplasm • cnewyllyn cell • transcription regulator complex Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • proses rythmig • negative regulation of transforming growth factor beta receptor signaling pathway • transcription, DNA-templated • GO:1901313 positive regulation of gene expression • negative regulation of cell migration • response to hormone • forebrain development • epithelial tube branching involved in lung morphogenesis • negative regulation of epithelial to mesenchymal transition • GO:1901227 negative regulation of transcription by RNA polymerase II • neuron migration • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • phospholipid metabolic process • pattern specification process • axon guidance • brain development • endoderm development • locomotory behavior • animal organ morphogenesis • telencephalon development • globus pallidus development • hippocampus development • cerebral cortex cell migration • forebrain dorsal/ventral pattern formation • forebrain neuron fate commitment • forebrain neuron differentiation • cerebral cortex GABAergic interneuron differentiation • cerebral cortex neuron differentiation • pituitary gland development • telencephalon cell migration • lung development • thyroid gland development • developmental induction • Leydig cell differentiation • positive regulation of circadian rhythm • GO:0045996 negative regulation of transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • anatomical structure formation involved in morphogenesis • neuron fate commitment • oligodendrocyte differentiation • lung saccule development • club cell differentiation • type II pneumocyte differentiation • cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7080	n/a
Ensembl	ENSG00000136352	n/a
UniProt	P43699	n/a
RefSeq (mRNA)	NM_001079668 NM_003317	n/a
RefSeq (protein)	NP_001073136 NP_003308	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NKX2-1 yw NKX2-1 a elwir hefyd yn NK2 homeobox 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NKX2-1.

• BCH
• BHC
• NK-2
• TEBP
• TTF1
• NKX2A
• NMTC1
• T/EBP
• TITF1
• TTF-1
• NKX2.1

Llyfryddiaeth

• "14q13 distal microdeletion encompassing NKX2-1 and PAX9: Patient report and refinement of the associated phenotype. ". Am J Med Genet A. 2016. PMID 27148860.
• "Thyroid Transcription Factor-1 Expression in Adenocarcinomas of the Bile Duct. ". Int J Surg Pathol. 2016. PMID 26316052.
• "Thyroid transcription factor 1 expression is associated with outcome of patients with non-squamous non-small cell lung cancer treated with pemetrexed-based chemotherapy. ". Tumour Biol. 2017. PMID 28218046.
• "Value of circulating tumor cells positive for thyroid transcription factor-1 (TTF-1) to predict recurrence and survival rates for endometrial carcinoma. ". J BUON. 2016. PMID 28039713.
• "Transcriptome and in Vitro Differentiation Profile of Human Embryonic Stem Cell Derived NKX2.1-Positive Neural Progenitors.". Stem Cell Rev. 2016. PMID 27539622.