NKX2-1

NKX2-1
Dynodwyr
Cyfenwau	NKX2-1, Nkx2-1, AV026640, Nkx2.1, T/EBP, Titf1, Ttf-1, BCH, BHC, NK-2, NKX2A, TEBP, TTF1, NMTC1, NK2 homeobox 1
Dynodwyr allanol	OMIM: 600635 HomoloGene: 2488 GeneCards: NKX2-1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • sequence-specific DNA binding; • GO:0001948, GO:0016582 protein binding; • enzyme binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • intronic transcription regulatory region sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cydrannau o'r gell	• nucleoplasm; • cnewyllyn cell; • transcription regulator complex;
Prosesau biolegol	• GO:0009373 regulation of transcription, DNA-templated; • proses rythmig; • negative regulation of transforming growth factor beta receptor signaling pathway; • transcription, DNA-templated; • GO:1901313 positive regulation of gene expression; • negative regulation of cell migration; • response to hormone; • forebrain development; • epithelial tube branching involved in lung morphogenesis; • negative regulation of epithelial to mesenchymal transition; • GO:1901227 negative regulation of transcription by RNA polymerase II; • neuron migration; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • phospholipid metabolic process; • pattern specification process; • axon guidance; • brain development; • endoderm development; • locomotory behavior; • animal organ morphogenesis; • telencephalon development; • globus pallidus development; • hippocampus development; • cerebral cortex cell migration; • forebrain dorsal/ventral pattern formation; • forebrain neuron fate commitment; • forebrain neuron differentiation; • cerebral cortex GABAergic interneuron differentiation; • cerebral cortex neuron differentiation; • pituitary gland development; • telencephalon cell migration; • lung development; • thyroid gland development; • developmental induction; • Leydig cell differentiation; • positive regulation of circadian rhythm; • GO:0045996 negative regulation of transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • anatomical structure formation involved in morphogenesis; • neuron fate commitment; • oligodendrocyte differentiation; • lung saccule development; • club cell differentiation; • type II pneumocyte differentiation; • cell differentiation;
	Sources:Amigo / QuickGO
Orthologau
	7080
	n/a
	ENSG00000136352
	n/a
	P43699
	n/a
	NM_001079668; NM_003317
	n/a
	NP_001073136; NP_003308
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NKX2-1 yw NKX2-1 a elwir hefyd yn NK2 homeobox 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q13.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NKX2-1.

BCH
BHC
NK-2
TEBP
TTF1
NKX2A
NMTC1
T/EBP
TITF1
TTF-1
NKX2.1

Llyfryddiaeth

"14q13 distal microdeletion encompassing NKX2-1 and PAX9: Patient report and refinement of the associated phenotype. ". Am J Med Genet A. 2016. PMID 27148860.
"Thyroid Transcription Factor-1 Expression in Adenocarcinomas of the Bile Duct. ". Int J Surg Pathol. 2016. PMID 26316052.
"Thyroid transcription factor 1 expression is associated with outcome of patients with non-squamous non-small cell lung cancer treated with pemetrexed-based chemotherapy. ". Tumour Biol. 2017. PMID 28218046.
"Value of circulating tumor cells positive for thyroid transcription factor-1 (TTF-1) to predict recurrence and survival rates for endometrial carcinoma. ". J BUON. 2016. PMID 28039713.
"Transcriptome and in Vitro Differentiation Profile of Human Embryonic Stem Cell Derived NKX2.1-Positive Neural Progenitors.". Stem Cell Rev. 2016. PMID 27539622.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] NKX2-1 - Cronfa NCBI

[1]

[2]