NFKB1

NFKB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1MDI, 1MDJ, 1MDK, 1NFI, 1SVC, 2DBF, 2O61, 3GUT
Dynodwyr
Cyfenwau	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50, CVID12, nuclear factor kappa B subunit 1, NF-kappa-B1, NF-kB, NF-kappabeta
Dynodwyr allanol	OMIM: 164011 HomoloGene: 2971 GeneCards: NFKB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • RNA polymerase II transcription regulatory region sequence-specific DNA binding • transcription factor binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • protein homodimerization activity • chromatin binding • GO:0001948, GO:0016582 protein binding • DNA binding • sequence-specific DNA binding • actinin binding • identical protein binding • GO:0000975 transcription cis-regulatory region binding • protein heterodimerization activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • mitocondria • cnewyllyn cell • I-kappaB/NF-kappaB complex • nucleoplasm • extracellular region • cytosol • secretory granule lumen • specific granule lumen Prosesau biolegol • cellular response to interleukin-6 • positive regulation of canonical Wnt signaling pathway • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • negative regulation of vitamin D biosynthetic process • Fc-epsilon receptor signaling pathway • cellular response to mechanical stimulus • NIK/NF-kappaB signaling • stress-activated MAPK cascade • negative regulation of inflammatory response • GO:0097285 apoptotic process • response to muscle stretch • GO:0009373 regulation of transcription, DNA-templated • stimulatory C-type lectin receptor signaling pathway • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of calcidiol 1-monooxygenase activity • positive regulation of hyaluronan biosynthetic process • membrane protein intracellular domain proteolysis • inflammatory response • I-kappaB kinase/NF-kappaB signaling • positive regulation of miRNA metabolic process • cellular response to nicotine • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of macrophage derived foam cell differentiation • positive regulation of NF-kappaB transcription factor activity • negative regulation of cholesterol transport • GO:0045996 negative regulation of transcription, DNA-templated • GO:0032697 negative regulation of cytokine production • positive regulation of lipid storage • cellular response to dsRNA • T cell receptor signaling pathway • positive regulation of type I interferon production • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0072468 signal transduction • cellular response to lipopolysaccharide • cellular response to interleukin-1 • innate immune response • negative regulation of apoptotic process • negative regulation of gene expression • neutrophil degranulation • cellular response to tumor necrosis factor • cellular response to angiotensin • interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4790	n/a
Ensembl	ENSG00000109320	n/a
UniProt	P19838	n/a
RefSeq (mRNA)	NM_001165412 NM_003998 NM_001319226 NM_001382625 NM_001382626 NM_001382627 NM_001382628	n/a
RefSeq (protein)	NP_001158884 NP_001306155 NP_003989 NP_001369554 NP_001369555 NP_001369556 NP_001369557 NP_001158884.1 NP_001306155.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NFKB1 yw NFKB1 a elwir hefyd yn Nuclear factor NF-kappa-B p105 subunit a Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (P105), isoform CRA_b (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q24.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NFKB1.

• p50
• KBF1
• p105
• EBP-1
• CVID12
• NF-kB1
• NFKB-p50
• NFkappaB
• NF-kappaB
• NFKB-p105
• NF-kappa-B

Llyfryddiaeth

• "Genes directly regulated by NF-κB in human hepatocellular carcinoma HepG2. ". Int J Biochem Cell Biol. 2017. PMID 28579529.
• "EBV induces persistent NF-κB activation and contributes to survival of EBV-positive neoplastic T- or NK-cells. ". PLoS One. 2017. PMID 28346502.
• "Elevated NF-κB signaling in Asherman syndrome patients and animal models. ". Oncotarget. 2017. PMID 28148903.
• "Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes. ". J Allergy Clin Immunol. 2017. PMID 28115215.
• "Mutant DD genotype of NFKB1 gene is associated with the susceptibility and severity of coronary artery disease.". J Mol Cell Cardiol. 2017. PMID 28088561.