NELFE

NELFE
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1X5P, 2BZ2, 2JX2
Dynodwyr
Cyfenwau	NELFE, D6S45, NELF-E, RD, RDBP, RDP, negative elongation factor complex member E
Dynodwyr allanol	OMIM: 154040 HomoloGene: 134736 GeneCards: NELFE
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleic acid binding • GO:0001948, GO:0016582 protein binding • chromatin binding • RNA binding Cydrannau o'r gell • cnewyllyn cell • nucleoplasm • NELF complex • Cellbilen • nuclear body Prosesau biolegol • negative regulation of transcription elongation from RNA polymerase II promoter • positive regulation of ERK1 and ERK2 cascade • positive regulation of viral transcription • transcription by RNA polymerase II • GO:0009373 regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of histone H3-K4 methylation • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of mRNA polyadenylation • transcription elongation from RNA polymerase II promoter • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7936	n/a
Ensembl	ENSG00000229363 ENSG00000206357 ENSG00000231044 ENSG00000204356 ENSG00000206268 ENSG00000233801	n/a
UniProt	P18615	n/a
RefSeq (mRNA)	NM_002904	n/a
RefSeq (protein)	NP_002895	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NELFE yw NELFE a elwir hefyd yn Negative elongation factor E a Negative elongation factor complex member E (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6p21.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NELFE.

• RD
• RDP
• RDBP
• D6S45
• NELF-E

Llyfryddiaeth

• "Structural studies on the RNA-recognition motif of NELF E, a cellular negative transcription elongation factor involved in the regulation of HIV transcription. ". Biochem J. 2006. PMID 16898873.
• "The human RD protein is closely related to nuclear RNA-binding proteins and has been highly conserved. ". Gene. 1990. PMID 2119325.
• "Negative elongation factor-mediated suppression of RNA polymerase II elongation of Kaposi's sarcoma-associated herpesvirus lytic gene expression. ". J Virol. 2012. PMID 22740393.
• "Overexpression of the RD RNA binding protein in hepatitis C virus-related hepatocellular carcinoma. ". Oncol Rep. 2012. PMID 22614758.
• "NELF-E RRM undergoes major structural changes in flexible protein regions on target RNA binding.". Biochemistry. 2008. PMID 18303858.