Neidio i'r cynnwys

NEIL1

Oddi ar Wicipedia
NEIL1
Strwythurau
PDBHuman UniProt search: PDBe RCSB
Dynodwyr
CyfenwauNEIL1, FPG1, NEI1, hFPG1, nei like DNA glycosylase 1
Dynodwyr allanolOMIM: 608844 HomoloGene: 11616 GeneCards: NEIL1
Patrwm RNA pattern
Rhagor o gyfeiriadau
Orthologau
SpeciesBod dynolLlygoden
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001256552
NM_024608
NM_001352519
NM_001352520

n/a

RefSeq (protein)

NP_001243481
NP_078884
NP_001339448
NP_001339449

n/a

Lleoliad (UCSC)n/an/a
PubMed search[1]n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NEIL1 yw NEIL1 a elwir hefyd yn Endonuclease 8-like 1 a Nei like DNA glycosylase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q24.2.[2]

Cyfystyron

[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NEIL1.

  • FPG1
  • NEI1
  • hFPG1

Llyfryddiaeth

[golygu | golygu cod]
  • "NEIL1 p.Gln282Stop variant is predominantly localized in the cytoplasm and exhibits reduced activity in suppressing mutations. ". Gene. 2015. PMID 26095805.
  • "Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: activity, structure, and the effect of editing. ". DNA Repair (Amst). 2014. PMID 24382305.
  • "NEIL1 is a candidate gene associated with common variable immunodeficiency in a patient with a chromosome 15q24 deletion. ". Clin Immunol. 2017. PMID 28093361.
  • "Ubiquitylation-dependent regulation of NEIL1 by Mule and TRIM26 is required for the cellular DNA damage response. ". Nucleic Acids Res. 2017. PMID 27924031.
  • "The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: DOMINANT NEGATIVE FUNCTION OF THE CTD.". J Biol Chem. 2015. PMID 26134572.

Cyfeiriadau

[golygu | golygu cod]
  1. "Human PubMed Reference:".
  2. NEIL1 - Cronfa NCBI