NEDD8

NEDD8
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1NDD, 1R4M, 1R4N, 1XT9, 2BKR, 2KO3, 2NVU, 3DBH, 3DBL, 3DBR, 3DQV, 3GZN, 4F8C, 4FBJ, 4HCP, 4P5O
Dynodwyr
Cyfenwau	NEDD8, NEDD-8, neural precursor cell expressed, developmentally down-regulated 8, NEDD8 ubiquitin like modifier
Dynodwyr allanol	OMIM: 603171 HomoloGene: 4485 GeneCards: NEDD8
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • ubiquitin protein ligase binding • protein tag Cydrannau o'r gell • cytosol • extracellular exosome • cnewyllyn cell • nucleoplasm • cytoplasm Prosesau biolegol • GO:0034613 protein localization • anatomical structure morphogenesis • transforming growth factor beta receptor signaling pathway • GO:1904578 response to organic cyclic compound • ubiquitin-dependent protein catabolic process • proteolysis • protein neddylation • protein deubiquitination • cellular iron ion homeostasis • protein ubiquitination • post-translational protein modification • modification-dependent protein catabolic process • regulation of proteolysis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4738	n/a
Ensembl	ENSG00000129559 ENSG00000285246	n/a
UniProt	Q15843	n/a
RefSeq (mRNA)	NM_006156	n/a
RefSeq (protein)	NP_006147	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NEDD8 yw NEDD8 a elwir hefyd yn Neural precursor cell expressed, developmentally down-regulated 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NEDD8.

• NEDD-8

Llyfryddiaeth

• "Distinct outcomes of CRL-Nedd8 pathway inhibition reveal cancer cell plasticity. ". Cell Death Dis. 2016. PMID 27906189.
• "NEDD8-mediated neddylation is required for human endometrial stromal proliferation and decidualization. ". Hum Reprod. 2015. PMID 26003431.
• "Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells. ". Cancer Biol Ther. 2015. PMID 25782162.
• "Localization and modulation of NEDD8 protein in the human placenta. ". In Vivo. 2013. PMID 23812220.
• "Structural mechanism of ubiquitin and NEDD8 deamidation catalyzed by bacterial effectors that induce macrophage-specific apoptosis.". Proc Natl Acad Sci U S A. 2012. PMID 23175788.