NEDD4

NEDD4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2KPZ, 2KQ0, 2M3O, 2XBB, 2XBF, 3B7Y, 4BBN, 4BE8, 4N7F, 4N7H, 5C91, 5AHT, 5C7J
Dynodwyr
Cyfenwau	NEDD4, NEDD4-1, RPF1, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase, NEDD4 E3 ubiquitin protein ligase
Dynodwyr allanol	OMIM: 602278 HomoloGene: 136740 GeneCards: NEDD4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein domain specific binding • GO:0050372 ubiquitin-protein transferase activity • sodium channel inhibitor activity • beta-2 adrenergic receptor binding • ubiquitin binding • GO:0001948, GO:0016582 protein binding • RNA polymerase binding • proline-rich region binding • phosphoserine residue binding • phosphothreonine residue binding • ionotropic glutamate receptor binding • transferase activity • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity Cydrannau o'r gell • cytoplasm • cytosol • Golgi apparatus • bilen • ubiquitin ligase complex • Cellbilen • apicolateral plasma membrane • cell cortex • perinuclear region of cytoplasm • chromatin • extracellular exosome • dendritic spine • glutamatergic synapse • postsynaptic cytosol Prosesau biolegol • protein targeting to lysosome • adaptive immune response • GO:1903364 positive regulation of protein catabolic process • blood vessel morphogenesis • negative regulation of sodium ion transport • cellular response to UV • endocardial cushion development • negative regulation of vascular endothelial growth factor receptor signaling pathway • protein K63-linked ubiquitination • regulation of membrane potential • negative regulation of sodium ion transmembrane transporter activity • regulation of ion transmembrane transport • negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage • outflow tract morphogenesis • receptor internalization • GO:1901227 negative regulation of transcription by RNA polymerase II • protein monoubiquitination • receptor catabolic process • nervous system development • regulation of dendrite morphogenesis • response to calcium ion • positive regulation of nucleocytoplasmic transport • neuromuscular junction development • protein ubiquitination • regulation of potassium ion transmembrane transporter activity • lysosomal transport • ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway • positive regulation of phosphatidylinositol 3-kinase signaling • progesterone receptor signaling pathway • GO:0022415 viral process • neuron projection development • GO:1904739 regulation of synapse organization • T cell activation • regulation of macroautophagy • glucocorticoid receptor signaling pathway • protein polyubiquitination • ubiquitin-dependent protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4734	n/a
Ensembl	ENSG00000069869	n/a
UniProt	P46934	n/a
RefSeq (mRNA)	NM_001284338 NM_001284339 NM_001284340 NM_006154 NM_198400 NM_001329212	n/a
RefSeq (protein)	NP_001271267 NP_001271268 NP_001271269 NP_001316141 NP_006145 NP_940682	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NEDD4 yw NEDD4 a elwir hefyd yn E3 ubiquitin-protein ligase NEDD4 a Neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q21.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NEDD4.

• RPF1
• NEDD4-1

Llyfryddiaeth

• "The E3 ubiquitin ligase NEDD4 is translationally upregulated and facilitates pancreatic cancer. ". Oncotarget. 2017. PMID 28423617.
• "NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt signaling. ". Gynecol Oncol. 2015. PMID 26193427.
• "[Association of NEDD4 gene polymorphisms with schizophrenia and its clinical characteristics in Chinese Han population]. ". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015. PMID 26037357.
• "A novel small-form NEDD4 regulates cell invasiveness and apoptosis to promote tumor metastasis. ". Oncotarget. 2015. PMID 25823820.
• "NEDD4: The founding member of a family of ubiquitin-protein ligases.". Gene. 2015. PMID 25527121.