NDC80

NDC80
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2IGP, 2VE7, 3IZ0
Dynodwyr
Cyfenwau	NDC80, HEC, HEC1, HsHec1, KNTC2, TID3, hskinetochore complex component, NDC80 kinetochore complex component
Dynodwyr allanol	OMIM: 607272 HomoloGene: 38141 GeneCards: NDC80
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • structural constituent of cytoskeleton • GO:0001948, GO:0016582 protein binding • identical protein binding Cydrannau o'r gell • cytosol • bilen • Cromosom • Ndc80 complex • chromosome, centromeric region • cnewyllyn cell • kinetochore • nucleoplasm • centrosome Prosesau biolegol • chromosome segregation • GO:0043148 mitotic spindle organization • Cellraniad • establishment of mitotic spindle orientation • mitotic sister chromatid segregation • cell cycle • attachment of spindle microtubules to kinetochore • sister chromatid cohesion • metaphase plate congression • attachment of mitotic spindle microtubules to kinetochore • positive regulation of mitotic cell cycle spindle assembly checkpoint • GO:0007067 Mitosis • kinetochore organization • positive regulation of protein localization to kinetochore Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10403	n/a
Ensembl	ENSG00000080986	n/a
UniProt	O14777	n/a
RefSeq (mRNA)	NM_006101	n/a
RefSeq (protein)	NP_006092	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NDC80 yw NDC80 a elwir hefyd yn Kinetochore protein NDC80 homolog a NDC80, kinetochore complex component (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 18, band 18p11.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NDC80.

• HEC
• HEC1
• TID3
• KNTC2
• HsHec1
• hsNDC80

Llyfryddiaeth

• "Multisite phosphorylation of the NDC80 complex gradually tunes its microtubule-binding affinity. ". Mol Biol Cell. 2015. PMID 25808492.
• "MAPping the Ndc80 loop in cancer: A possible link between Ndc80/Hec1 overproduction and cancer formation. ". Bioessays. 2015. PMID 25557589.
• "Mechanism of Ska Recruitment by Ndc80 Complexes to Kinetochores. ". Dev Cell. 2017. PMID 28535377.
• "NDC80 promotes proliferation and metastasis of colon cancer cells. ". Genet Mol Res. 2016. PMID 27173328.
• "The mitotic regulator Hec1 is a critical modulator of prostate cancer through the long non-coding RNA BX647187 in vitro.". Biosci Rep. 2015. PMID 26612002.