NCOR1

NCOR1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2EQR, 3H52, 3KMZ, 3N00, 4MDD, 4WVD
Dynodwyr
Cyfenwau	NCOR1, N-CoR, N-CoR1, PPP1R109, TRAC1, hN-CoR, nuclear receptor corepressor 1
Dynodwyr allanol	OMIM: 600849 HomoloGene: 38166 GeneCards: NCOR1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001106 transcription corepressor activity • histone deacetylase binding • thyroid hormone receptor binding • GO:0001948, GO:0016582 protein binding • nuclear receptor binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • chromatin binding • sequence-specific DNA binding Cydrannau o'r gell • histone deacetylase complex • bilen • transcription repressor complex • Sin3 complex • spindle microtubule • cnewyllyn cell • nucleoplasm • cytosol • mitotic spindle Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • negative regulation of production of miRNAs involved in gene silencing by miRNA • spindle assembly • negative regulation of JNK cascade • regulation of fatty acid transport • Rhythm circadaidd • transcription, DNA-templated • regulation of lipid metabolic process • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of androgen receptor signaling pathway • locomotor rhythm • proses rythmig Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9611	n/a
Ensembl	ENSG00000141027	n/a
UniProt	O75376	n/a
RefSeq (mRNA)	NM_001190438 NM_001190440 NM_006311	n/a
RefSeq (protein)	NP_001177367 NP_001177369 NP_006302	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NCOR1 yw NCOR1 a elwir hefyd yn Nuclear receptor corepressor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17p12-p11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NCOR1.

• N-CoR
• TRAC1
• N-CoR1
• hN-CoR
• PPP1R109

Llyfryddiaeth

• "Akt-induced phosphorylation of N-CoR at serine 1450 contributes to its misfolded conformational dependent loss (MCDL) in acute myeloid leukemia of the M5 subtype. ". PLoS One. 2013. PMID 23940660.
• "Aberrant nuclear repressor coreceptor 1 localization in human retinoblastoma. ". Ophthalmic Res. 2013. PMID 23295231.
• "Autoregulatory loop of nuclear corepressor 1 expression controls invasion, tumor growth, and metastasis. ". Proc Natl Acad Sci U S A. 2016. PMID 26729869.
• "Cytoplasmic accumulation of NCoR in malignant melanoma: consequences of altered gene repression and prognostic significance. ". Oncotarget. 2015. PMID 25823659.
• "NCoR controls glioblastoma tumor cell characteristics.". Neuro Oncol. 2014. PMID 24335696.