NCOA3

NCOA3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1KBH, 3L3X, 3L3Z
Dynodwyr
Cyfenwau	NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP, nuclear receptor coactivator 3
Dynodwyr allanol	OMIM: 601937 HomoloGene: 4764 GeneCards: NCOA3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein dimerization activity • protein N-terminus binding • GO:0001105 transcription coactivator activity • thyroid hormone receptor binding • histone acetyltransferase activity • GO:0001948, GO:0016582 protein binding • androgen receptor binding • nuclear receptor binding • nuclear receptor coactivator activity • acyltransferase activity • protein heterodimerization activity • disordered domain specific binding • RNA polymerase II complex binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • nucleoplasm • extracellular exosome • cnewyllyn cell • cytosol • GO:0009327 protein-containing complex Prosesau biolegol • androgen receptor signaling pathway • regulation of RNA biosynthetic process • GO:0009373 regulation of transcription, DNA-templated • positive regulation of keratinocyte differentiation • cellular response to estradiol stimulus • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:1901313 positive regulation of gene expression • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • receptor transactivation • intracellular receptor signaling pathway • histone acetylation • cellular response to hormone stimulus • cell dedifferentiation • positive regulation of stem cell population maintenance • regulation of stem cell division Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8202	n/a
Ensembl	ENSG00000124151	n/a
UniProt	Q9Y6Q9	n/a
RefSeq (mRNA)	NM_181659 NM_001174087 NM_001174088 NM_006534	n/a
RefSeq (protein)	NP_001167558 NP_001167559 NP_006525 NP_858045	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NCOA3 yw NCOA3 a elwir hefyd yn Nuclear receptor coactivator 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20q13.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NCOA3.

• ACTR
• AIB1
• RAC3
• SRC3
• pCIP
• AIB-1
• CTG26
• SRC-3
• CAGH16
• KAT13B
• TNRC14
• TNRC16
• TRAM-1
• bHLHe42

Llyfryddiaeth

• "Overexpression of SRC-3 promotes esophageal squamous cell carcinoma aggressiveness by enhancing cell growth and invasiveness. ". Cancer Med. 2016. PMID 27781415.
• "Inhibition of SRC-3 enhances sensitivity of human cancer cells to histone deacetylase inhibitors. ". Biochem Biophys Res Commun. 2016. PMID 27425252.
• "Amplified in Breast Cancer Regulates Transcription and Translation in Breast Cancer Cells. ". Neoplasia. 2016. PMID 26936396.
• "Association of NCOA3 polymorphisms with Dyslipidemia in the Chinese Han population. ". Lipids Health Dis. 2015. PMID 26449542.
• "SRC3 Phosphorylation at Serine 543 Is a Positive Independent Prognostic Factor in ER-Positive Breast Cancer.". Clin Cancer Res. 2016. PMID 26369632.