NCOA1

NCOA1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FM6, 1FM9, 1K74, 1K7L, 1KV6, 1K4W, 1N4H, 1NQ7, 1NRL, 1P8D, 1PZL, 1RDT, 1TFC, 1U3R, 1U3S, 1X76, 1XIU, 1XV9, 1XVP, 1YY4, 1ZAF, 2A3I, 2C52, 2FVJ, 2GTK, 2HBH, 2HC4, 2HCD, 2HFP, 2NPA, 2NV7, 2P54, 2PRG, 3BEJ, 3BQD, 3CTB, 3CWD, 3DCT, 3DCU, 3DR1, 3ET1, 3ET3, 3FEI, 3FEJ, 3FUR, 3FXV, 3G8I, 3G9E, 3GYT, 3GYU, 3H0A, 3HC5, 3HC6, 3HVL, 3IPQ, 3IPS, 3IPU, 3KMR, 3LMP, 3OKH, 3OKI, 3OLF, 3OLL, 3OLS, 3OMK, 3OMM, 3OMO, 3OMP, 3OMQ, 3OOF, 3OOK, 3P88, 3P89, 3QT0, 3RUT, 3RUU, 3RVF, 3S9S, 3T03, 3UU7, 3UUA, 3UUD, 3V9Y, 3VN2, 4DK7, 4DK8, 4DM6, 4DM8, 4DQM, 4F9M, 4FGY, 4G1D, 4G1Y, 4G1Z, 4G20, 4G21, 4G2H, 4HEE, 4J5X, 4JYG, 4JYH, 4JYI, 4MG5, 4MG6, 4MG7, 4MG8, 4MG9, 4MGA, 4MGB, 4MGC, 4MGD, 4TUZ, 4TV1, 5AVI, 5AVL, 4Y29, 4RUJ, 4RUP, 5A86, 5E7V, 4UDB, 4UDA, 5AZT, 5HJS
Dynodwyr
Cyfenwau	NCOA1, F-SRC-1, KAT13A, RIP160, SRC1, bHLHe42, bHLHe74, nuclear receptor coactivator 1
Dynodwyr allanol	OMIM: 602691 HomoloGene: 7859 GeneCards: NCOA1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • DNA binding • GO:0001105 transcription coactivator activity • protein dimerization activity • protein N-terminus binding • transcription factor binding • chromatin binding • histone acetyltransferase activity • GO:0001948, GO:0016582 protein binding • androgen receptor binding • enzyme binding • acyltransferase activity • nuclear receptor coactivator activity • aryl hydrocarbon receptor binding • nuclear receptor binding • estrogen receptor binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • progesterone receptor binding • retinoic acid receptor binding • GO:0032403 protein-containing complex binding • retinoid X receptor binding Cydrannau o'r gell • cnewyllyn cell • nucleoplasm • cytosol • Cellbilen • GO:0009327 protein-containing complex • cytoplasm • neuron projection Prosesau biolegol • androgen receptor signaling pathway • regulation of RNA biosynthetic process • GO:0009373 regulation of transcription, DNA-templated • cellular response to Thyroglobulin triiodothyronine • regulation of cellular response to drug • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • labyrinthine layer morphogenesis • positive regulation of neuron differentiation • bile acid and bile salt transport • positive regulation of apoptotic process • histone H4 acetylation • regulation of thyroid hormone mediated signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • intracellular receptor signaling pathway • positive regulation of transcription from RNA polymerase II promoter by galactose • regulation of lipid metabolic process • transcription by RNA polymerase II • cellular response to hormone stimulus • lactation • male gonad development • response to hormone • cerebellum development • hippocampus development • hypothalamus development • cerebral cortex development • response to estradiol • response to retinoic acid • response to progesterone • estrous cycle • positive regulation of female receptivity • male mating behavior Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8648	n/a
Ensembl	ENSG00000084676	n/a
UniProt	Q15788	n/a
RefSeq (mRNA)	NM_003743 NM_147223 NM_147233 NM_001362950 NM_001362952 NM_001362954 NM_001362955	n/a
RefSeq (protein)	NP_003734 NP_671756 NP_671766 NP_001349879 NP_001349881 NP_001349883 NP_001349884	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NCOA1 yw NCOA1 a elwir hefyd yn Nuclear receptor coactivator 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2p23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NCOA1.

• SRC1
• KAT13A
• RIP160
• F-SRC-1
• bHLHe42
• bHLHe74

Llyfryddiaeth

• "NCOA1 is a novel susceptibility gene for multiple myeloma in the Chinese population: A case-control study. ". PLoS One. 2017. PMID 28264017.
• "Association between SRC-1 gene polymorphisms and coronary artery aneurysms formation in Taiwanese children with Kawasaki disease. ". J Clin Lab Anal. 2014. PMID 24652666.
• "Steroid receptor coactivator 1 is an integrator of glucose and NAD+/NADH homeostasis. ". Mol Endocrinol. 2014. PMID 24438340.
• "A SNP in steroid receptor coactivator-1 disrupts a GSK3β phosphorylation site and is associated with altered tamoxifen response in bone. ". Mol Endocrinol. 2012. PMID 22174377.
• "Human papillomavirus E7 oncoprotein dysregulates steroid receptor coactivator 1 localization and function.". J Virol. 2006. PMID 16775354.