NAMPT

NAMPT
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2E5B, 2E5C, 2E5D, 2GVG, 2GVJ, 3DGR, 3DHD, 3DHF, 3DKJ, 3DKL, 4JNM, 4JR5, 4KFN, 4KFO, 4KFP, 4L4L, 4L4M, 4LTS, 4LV9, 4LVA, 4LVB, 4LVD, 4LVF, 4LVG, 4LWW, 4M6P, 4M6Q, 4N9B, 4N9C, 4N9D, 4N9E, 4O0Z, 4O10, 4O12, 4O13, 4O14, 4O15, 4O16, 4O17, 4O18, 4O19, 4O1A, 4O1B, 4O1C, 4O1D, 4O28, 4WQ6
Dynodwyr
Cyfenwau	NAMPT, 1110035O14Rik, PBEF, PBEF1, VF, VISFATIN, nicotinamide phosphoribosyltransferase
Dynodwyr allanol	OMIM: 608764 HomoloGene: 4201 GeneCards: NAMPT
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • cytokine activity • protein homodimerization activity • glycosyltransferase activity • GO:0001948, GO:0016582 protein binding • nicotinate-nucleotide diphosphorylase (carboxylating) activity • nicotinamide phosphoribosyltransferase activity • identical protein binding • catalytic activity Cydrannau o'r gell • cytoplasm • cytosol • extracellular region • cell junction • extracellular exosome • cnewyllyn cell • extracellular space • nuclear speck • Cellbilen Prosesau biolegol • pyridine nucleotide biosynthetic process • GO:1901047 insulin receptor signaling pathway • GO:1904578 response to organic cyclic compound • NAD biosynthetic process • proses rythmig • female pregnancy • cell-cell signaling • positive regulation of nitric-oxide synthase biosynthetic process • circadian regulation of gene expression • Rhythm circadaidd • positive regulation of cell population proliferation • adipose tissue development • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of smooth muscle cell proliferation • GO:0072468 signal transduction • NAD biosynthesis via nicotinamide riboside salvage pathway • regulation of signaling receptor activity • microglial cell activation • GO:0010260 heneiddio • negative regulation of autophagy • regulation of lung blood pressure • neuron death • cellular response to ionizing radiation • cellular response to oxygen-glucose deprivation • cellular response to amyloid-beta • response to D-galactose • negative regulation of cellular senescence Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10135	n/a
Ensembl	ENSG00000105835	n/a
UniProt	P43490	n/a
RefSeq (mRNA)	NM_005746 NM_182790	n/a
RefSeq (protein)	NP_005737	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NAMPT yw NAMPT a elwir hefyd yn Nicotinamide phosphoribosyltransferase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q22.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NAMPT.

• VF
• PBEF
• PBEF1
• VISFATIN
• 1110035O14Rik

Llyfryddiaeth

• "Nicotinamide Phosphoribosyl Transferase a Reliable Marker of Progression in Cervical Dysplasia.". Anticancer Res. 2017. PMID 28870901.
• "NAMPT serum levels are selectively elevated in acute infectious disease and in acute relapse of chronic inflammatory diseases in children.". PLoS One. 2017. PMID 28837586.
• "Identification of novel resistance mechanisms to NAMPT inhibition via the de novo NAD+ biosynthesis pathway and NAMPT mutation.". Biochem Biophys Res Commun. 2017. PMID 28756225.
• "Visfatin mediates doxorubicin resistance in human colorectal cancer cells via up regulation of multidrug resistance 1 (MDR1).". Cancer Chemother Pharmacol. 2017. PMID 28667355.
• "Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair.". Cancer Res. 2017. PMID 28507103.