MYOD1

MYOD1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1MDY
Dynodwyr
Cyfenwau	MYOD1, MYF3, MYOD, PUM, bHLHc1, myogenic differentiation 1, MYODRIF
Dynodwyr allanol	OMIM: 159970 HomoloGene: 7857 GeneCards: MYOD1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • protein dimerization activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • chromatin binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • E-box binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • enzyme binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • chromatin DNA binding • ubiquitin protein ligase binding • GO:0001105 transcription coactivator activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • promoter-specific chromatin binding Cydrannau o'r gell • transcription regulator complex • nucleoplasm • Myoffibril • cnewyllyn cell • cytoplasm • cytosol • nuclear body Prosesau biolegol • cell differentiation • myotube differentiation • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • cellular response to starvation • muscle cell fate commitment • cellular response to estradiol stimulus • skeletal muscle fiber adaptation • muscle organ development • regulation of alternative mRNA splicing, via spliceosome • myotube cell development • positive regulation of skeletal muscle fiber development • negative regulation of myoblast proliferation • transcription, DNA-templated • multicellular organism development • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • protein phosphorylation • regulation of RNA splicing • positive regulation of myoblast fusion • myoblast fate determination • cellular response to glucocorticoid stimulus • positive regulation of myoblast differentiation • skeletal muscle fiber development • histone H3 acetylation • myotube differentiation involved in skeletal muscle regeneration • histone H4 acetylation • skeletal muscle cell differentiation • positive regulation of skeletal muscle tissue regeneration • regulation of gene expression • striated muscle cell differentiation • cellular response to oxygen levels • myoblast fusion • myoblast differentiation • skeletal muscle tissue development • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • positive regulation of muscle cell differentiation • cellular response to tumor necrosis factor • positive regulation of snRNA transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4654	n/a
Ensembl	ENSG00000129152	n/a
UniProt	P15172	n/a
RefSeq (mRNA)	NM_002478	n/a
RefSeq (protein)	NP_002469	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MYOD1 yw MYOD1 a elwir hefyd yn Myogenic differentiation 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11p15.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MYOD1.

• PUM
• MYF3
• MYOD
• bHLHc1

Llyfryddiaeth

• "Incomplete MyoD-induced transdifferentiation is associated with chromatin remodeling deficiencies. ". Nucleic Acids Res. 2017. PMID 28977539.
• "Deficiency of the myogenic factor MyoD causes a perinatally lethal fetal akinesia. ". J Med Genet. 2016. PMID 26733463.
• "A MYOD1 mutation cooperates with PI3K pathway activation in ERMS. ". Cancer Discov. 2014. PMID 25002625.
• "Activation of muscle enhancers by MyoD and epigenetic modifiers. ". J Cell Biochem. 2014. PMID 24905980.
• "Recurrent MYOD1 mutations in pediatric and adult sclerosing and spindle cell rhabdomyosarcomas: evidence for a common pathogenesis.". Genes Chromosomes Cancer. 2014. PMID 24824843.