MYO6

MYO6
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2N11, 2N13, 2N0Z, 2N10, 2N12
Dynodwyr
Cyfenwau	MYO6, DFNA22, DFNB37, myosin VI, Myo6-008, Myo6-007
Dynodwyr allanol	OMIM: 600970 HomoloGene: 56417 GeneCards: MYO6
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytoskeletal motor activity • actin filament binding • ATP binding • calmodulin binding • GO:0001948, GO:0016582 protein binding • minus-end directed microfilament motor activity • ADP binding • actin binding • nucleotide binding • cadherin binding • identical protein binding Cydrannau o'r gell • myosin complex • cnewyllyn cell • intracellular membrane-bounded organelle • cell projection • ruffle membrane • RNA polymerase II, holoenzyme • nucleoplasm • lysosomal membrane • perinuclear region of cytoplasm • clathrin-coated endocytic vesicle • apical part of cell • clathrin-coated vesicle membrane • ruffle • cytosol • extracellular exosome • bilen • clathrin-coated pit • filamentous actin • Cellbilen • nuclear membrane • cytoplasm • cell cortex • microvillus • Golgi apparatus • unconventional myosin complex • endocytic vesicle • GO:0016023 cytoplasmic vesicle • Microffilament • GO:0009327 protein-containing complex • clathrin-coated vesicle • filopodium Prosesau biolegol • intracellular protein transport • actin filament-based movement • regulation of secretion • sensory perception of sound • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • protein transport • endocytosis • DNA damage response, signal transduction by p53 class mediator • GO:0015915 transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4646	n/a
Ensembl	ENSG00000196586	n/a
UniProt	Q9UM54	n/a
RefSeq (mRNA)	NM_001300899 NM_004999 NM_001368136 NM_001368137 NM_001368138 NM_001368139 NM_001368140 NM_001368865 NM_001368866	n/a
RefSeq (protein)	NP_001287828 NP_004990 NP_001355065 NP_001355066 NP_001355067 NP_001355068 NP_001355069 NP_001355794 NP_001355795	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MYO6 yw MYO6 a elwir hefyd yn Myosin VI (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6q14.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MYO6.

• DFNA22
• DFNB37
• Myo6-007
• Myo6-008

Llyfryddiaeth

• "Exome Sequencing Identifies a Novel Nonsense Mutation of MYO6 as the Cause of Deafness in a Brazilian Family. ". Ann Hum Genet. 2018. PMID 29044474.
• "Knockdown of Myosin 6 inhibits proliferation of oral squamous cell carcinoma cells. ". J Oral Pathol Med. 2016. PMID 27561828.
• "Overexpression of myosin VI regulates gastric cancer cell progression. ". Gene. 2016. PMID 27515005.
• "Loss of cargo binding in the human myosin VI deafness mutant (R1166X) leads to increased actin filament binding. ". Biochem J. 2016. PMID 27474411.
• "Downregulation of myosin VI reduced cell growth and increased apoptosis in human colorectal cancer.". Acta Biochim Biophys Sin (Shanghai). 2016. PMID 27044563.