MYO5A

MYO5A
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4J5L, 4LX1, 4LX2, 4LLI, 4D07
Dynodwyr
Cyfenwau	MYO5A, GS1, MYH12, MYO5, MYR12, myosin VA
Dynodwyr allanol	OMIM: 160777 HomoloGene: 20100 GeneCards: MYO5A
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • nucleotide binding; • calmodulin binding; • microfilament motor activity; • actin binding; • cytoskeletal motor activity; • ATP binding; • RNA binding; • disordered domain specific binding; • identical protein binding; • GO:0001948, GO:0016582 protein binding; • actin filament binding;
Cydrannau o'r gell	• cytoplasm; • recycling endosome; • fesigl; • cytosol; • late endosome; • Golgi apparatus; • bilen; • growth cone; • ruffle; • melanosome; • insulin-responsive compartment; • photoreceptor outer segment; • peroxisome; • secretory granule; • microtubule plus-end; • filopodium tip; • neuronal cell body; • early endosome; • Reticwlwm endoplasmig; • Microffilament; • neuron projection; • lysosome; • actomyosin; • intermediate filament; • extracellular exosome; • myosin complex; • unconventional myosin complex; • smooth endoplasmic reticulum; • postsynapse; • glutamatergic synapse;
Prosesau biolegol	• regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; • melanin biosynthetic process; • synapse organization; • insulin secretion; • secretory granule localization; • melanosome localization; • actin filament-based movement; • post-Golgi vesicle-mediated transport; • odontogenesis; • endoplasmic reticulum localization; • melanin metabolic process; • regulation of Golgi organization; • long-chain fatty acid biosynthetic process; • melanosome transport; • cellular response to insulin stimulus; • vesicle transport along actin filament; • protein transport; • developmental pigmentation; • myelination; • pigmentation; • protein localization to plasma membrane; • melanocyte differentiation; • locomotion involved in locomotory behavior; • vesicle-mediated transport; • golwg; • exocytosis; • chemical synaptic transmission; • hair follicle maturation; • GO:0015915 transport; • establishment of endoplasmic reticulum localization to postsynapse; • regulation of postsynaptic cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologau
	4644
	n/a
	ENSG00000197535
	n/a
	Q9Y4I1
	n/a
	NM_000259; NM_001142495; NM_001382347; NM_001382348; NM_001382349
	n/a
	NP_000250; NP_001135967; NP_001369276; NP_001369277; NP_001369278
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MYO5A yw MYO5A a elwir hefyd yn Myosin VA (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q21.2.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MYO5A.

GS1
MYO5
MYH12
MYR12

Llyfryddiaeth[golygu | golygu cod]

"The Globular Tail Domain of Myosin-5a Functions as a Dimer in Regulating the Motor Activity. ". J Biol Chem. 2016. PMID 27129208.
"Myosin-Va contributes to manifestation of malignant-related properties in melanoma cells. ". J Invest Dermatol. 2013. PMID 23652798.
"Roles for myosin Va in RNA transport and turnover. ". Biochem Soc Trans. 2012. PMID 23176491.
"Myosin Va is required for P body but not stress granule formation. ". J Biol Chem. 2011. PMID 21245139.
"Myosin Va enhances secretion of herpes simplex virus 1 virions and cell surface expression of viral glycoproteins.". J Virol. 2010. PMID 20631136.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] MYO5A - Cronfa NCBI

[1]

[2]