MYB

MYB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GUU, 1GV2, 1GV5, 1GVD, 1H88, 1H89, 1IDY, 1IDZ, 1MBE, 1MBF, 1MBG, 1MBH, 1MBJ, 1MBK, 1MSE, 1MSF, 1SB0, 2AGH
Dynodwyr
Cyfenwau	MYB, Cmyb, c-myb, c-myb_CDS, efg, MYB proto-oncogene, transcription factor
Dynodwyr allanol	OMIM: 189990 HomoloGene: 31311 GeneCards: MYB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • nuclear matrix • cnewyllyn cell • nucleoplasm Prosesau biolegol • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • chromatin remodeling • GO:0045996 negative regulation of transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of histone H3-K4 methylation • transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of histone H3-K9 methylation • positive regulation of T-helper cell differentiation • transcription by RNA polymerase II • GO:0007067 Mitosis • response to hypoxia • positive regulation of collagen biosynthetic process • positive regulation of neuron apoptotic process • positive regulation of smooth muscle cell proliferation • positive regulation of glial cell proliferation • cellular response to hydrogen peroxide • cellular response to retinoic acid • positive regulation of transforming growth factor beta production • positive regulation of neuron death • positive regulation of hepatic stellate cell proliferation • positive regulation of hepatic stellate cell activation • positive regulation of testosterone secretion • regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4602	n/a
Ensembl	ENSG00000118513	n/a
UniProt	P10242 Q708E1	n/a
RefSeq (mRNA)	NM_001130172 NM_001130173 NM_001161656 NM_001161657 NM_001161658 NM_001161659 NM_001161660 NM_005375	n/a
RefSeq (protein)	NP_001123644 NP_001123645 NP_001155128 NP_001155129 NP_001155130 NP_001155131 NP_001155132 NP_005366	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MYB yw MYB a elwir hefyd yn C-myb v-myb myeloblastosis viral oncogene homologue (avian), exon 1 and joined CDS a MYB proto-oncogene, transcription factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6q23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MYB.

• efg
• Cmyb
• c-myb
• c-myb_CDS

Llyfryddiaeth

• "A c-Myb mutant causes deregulated differentiation due to impaired histone binding and abrogated pioneer factor function. ". Nucleic Acids Res. 2017. PMID 28472346.
• "Adenoid cystic carcinoma of the lacrimal gland is frequently characterized by MYB rearrangement. ". Eye (Lond). 2017. PMID 28085142.
• "c-Myb Overexpression in Cytology Smears of Tracheobronchial and Pulmonary Adenoid Cystic Carcinomas. ". Acta Cytol. 2017. PMID 27974718.
• "The incidence of MYB gene breaks in adenoid cystic carcinoma of the salivary glands and its prognostic significance. ". Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016. PMID 27174194.
• "Overexpression of MYB drives proliferation of CYLD-defective cylindroma cells.". J Pathol. 2016. PMID 26969893.