MVP

MVP
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1Y7X
Dynodwyr
Cyfenwau	MVP, LRP, VAULT1, major vault protein
Dynodwyr allanol	OMIM: 605088 HomoloGene: 3752 GeneCards: MVP
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein phosphatase binding • GO:0001948, GO:0016582 protein binding • protein kinase binding • identical protein binding Cydrannau o'r gell • cytoplasm • perinuclear region of cytoplasm • nuclear pore • extracellular exosome • Cytosgerbwd • bilen • cnewyllyn cell • extracellular region • cytosol • secretory granule lumen • ficolin-1-rich granule lumen Prosesau biolegol • protein transport • mRNA transport • negative regulation of protein tyrosine kinase activity • ERBB signaling pathway • negative regulation of signaling • negative regulation of protein autophosphorylation • neutrophil degranulation • GO:0015915 transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9961	n/a
Ensembl	ENSG00000013364	n/a
UniProt	Q14764	n/a
RefSeq (mRNA)	NM_017458 NM_001293204 NM_001293205 NM_005115	n/a
RefSeq (protein)	NP_001280133 NP_001280134 NP_005106 NP_059447 NP_001280134.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MVP yw MVP a elwir hefyd yn Major vault protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16p11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MVP.

• LRP
• VAULT1

Llyfryddiaeth

• "Molecular basis for the expression of major vault protein induced by hyperosmotic stress in SW620 human colon cancer cells. ". Int J Mol Med. 2013. PMID 23820674.
• "Major vault protein (MVP) gene polymorphisms and drug resistance in mesial temporal lobe epilepsy with hippocampal sclerosis. ". Gene. 2013. PMID 23751308.
• "Mechanisms underlying lung resistance-related protein (LRP)-mediated doxorubicin resistance of non-small cell lung cancer cells. ". Chin J Physiol. 2016. PMID 27817195.
• "Absence of association between major vault protein (MVP) gene polymorphisms and drug resistance in Chinese Han patients with partial epilepsy. ". J Neurol Sci. 2015. PMID 26476776.
• "Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis.". Oncotarget. 2013. PMID 24243798.