MTOR

MTOR
Strwythurau PDB Orthologau:PDBe RCSB Rhestr o ddynodwyr PDB 4JT6, 1AUE, 1FAP, 1NSG, 2FAP, 2GAQ, 2NPU, 2RSE, 3FAP, 4DRH, 4DRI, 4DRJ, 4FAP, 4JSN, 4JSP, 4JSV, 4JSX, 4JT5, 5FLC
Dynodwyr
Cyfenwau	MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS, mechanistic target of rapamycin, mechanistic target of rapamycin kinase
Dynodwyr allanol	OMIM: 601231 MGI: 1928394 HomoloGene: 3637 GeneCards: MTOR
Lleoliad y genyn (llygoedn) Cr. Cromosom 4 (llygoden) Band 4 E2|4 78.76 cM Start 148,448,611 bp End 148,557,683 bp
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • RNA polymerase III type 1 promoter DNA binding • protein domain specific binding • TFIIIC-class transcription factor binding • kinase activity • ATP binding • RNA polymerase III type 3 promoter DNA binding • protein serine/threonine kinase activity • transferase activity • ribosome binding • protein binding • protein kinase binding • nucleotide binding • phosphoprotein binding • RNA polymerase III type 2 promoter DNA binding • protein kinase activity • macromolecular complex binding • identical protein binding • translation regulator activity Cydrannau o'r gell • cytoplasm • cytosol • phosphatidylinositol 3-kinase complex • membrane • Mitocondria • TORC1 complex • organelle membrane • macromolecular complex • mitochondrial outer membrane • Reticwlwm endoplasmig • TORC2 complex • Golgi apparatus • intracellular membrane-bounded organelle • nucleoplasm • neuronal cell body • PML body • endoplasmic reticulum membrane • Golgi membrane • lysosomal membrane • dendrite • endomembrane system • cnewyllyn cell • lysosome • glutamatergic synapse • postsynaptic cytosol Prosesau biolegol • germ cell development • positive regulation of protein phosphorylation • response to amino acid • positive regulation of lipid biosynthetic process • positive regulation of actin filament polymerization • positive regulation of skeletal muscle hypertrophy • positive regulation of granulosa cell proliferation • regulation of carbohydrate utilization • post-embryonic development • positive regulation of dendritic spine development • positive regulation of translation • positive regulation of eating behavior • cell aging • protein phosphorylation • mRNA stabilization • cell projection organization • regulation of glycogen biosynthetic process • positive regulation of cell growth involved in cardiac muscle cell development • positive regulation of neuron maturation • positive regulation of glial cell proliferation • cellular response to hypoxia • negative regulation of cell size • response to cocaine • positive regulation of protein kinase B signaling • cardiac muscle contraction • maternal process involved in female pregnancy • ruffle organization • regulation of GTPase activity • cardiac muscle cell development • positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter • regulation of membrane permeability • response to insulin • regulation of myelination • regulation of fatty acid beta-oxidation • regulation of osteoclast differentiation • positive regulation of cholangiocyte proliferation • regulation of protein kinase B signaling • spinal cord development • positive regulation of peptidyl-tyrosine phosphorylation • social organism behavior • autophosphorylation • negative regulation of cholangiocyte apoptotic process • regulation of brown fat cell differentiation • regulation of protein kinase activity • negative regulation of protein phosphorylation • positive regulation of oligodendrocyte differentiation • regulation of carbohydrate metabolic process • regulation of actin cytoskeleton organization • voluntary musculoskeletal movement • phosphorylation • multicellular organism growth • negative regulation of muscle atrophy • wound healing • positive regulation of neurogenesis • response to morphine • positive regulation of sensory perception of pain • protein catabolic process • 'de novo' pyrimidine nucleobase biosynthetic process • cellular response to nutrient levels • energy reserve metabolic process • peptidyl-threonine phosphorylation • positive regulation of transcription from RNA polymerase III promoter • positive regulation of smooth muscle cell proliferation • visual learning • positive regulation of myotube differentiation • positive regulation of cell death • positive regulation of endothelial cell proliferation • negative regulation of iodide transmembrane transport • cardiac muscle tissue development • positive regulation of nitric oxide biosynthetic process • regulation of response to food • heart morphogenesis • positive regulation of neuron death • cardiac cell development • negative regulation of protein ubiquitination • brain development • positive regulation of gene expression • negative regulation of NFAT protein import into nucleus • long-term memory • heart valve morphogenesis • peptidyl-serine phosphorylation • cell cycle arrest • positive regulation of neuron projection development • regulation of cellular response to heat • positive regulation of lamellipodium assembly • positive regulation of stress fiber assembly • signal transduction • regulation of protein phosphorylation • negative regulation of macroautophagy • anoikis • TOR signaling • DNA repair • regulation of cell size • negative regulation of autophagy • positive regulation of epithelial to mesenchymal transition • regulation of macroautophagy • cellular response to amino acid starvation • positive regulation of keratinocyte migration • cellular response to amino acid stimulus • cellular response to leucine • positive regulation of wound healing, spreading of epidermal cells • cellular response to leucine starvation • cellular response to starvation • TORC1 signaling • growth • regulation of cell growth • response to nutrient • activation of protein kinase B activity • T-helper 1 cell lineage commitment • response to activity • positive regulation of phosphoprotein phosphatase activity • negative regulation of calcineurin-NFAT signaling cascade • regulation of translation at synapse, modulating synaptic transmission • positive regulation of cytoplasmic translational initiation • response to nutrient levels Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2475	56717
Ensembl	ENSG00000198793	ENSMUSG00000028991
UniProt	P42345	Q9JLN9
RefSeq (mRNA)	NM_004958	NM_020009
RefSeq (protein)	NP_004949	NP_064393
Lleoliad (UCSC)	n/a	Chr : 148.45 – 148.56 Mb
PubMed search
Wicidata
Gweld/Golygu Bod dynol Gweld/Golygu Llygoden

Protein sy'n cael ei godio yn y corff dynol gan y genyn MTOR yw MTOR a elwir hefyd yn Mechanistic target of rapamycin kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p36.22.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MTOR.

• SKS
• FRAP
• FRAP1
• FRAP2
• RAFT1
• RAPT1

Llyfryddiaeth

• "Identification of single nucleotide polymorphisms of the PI3K-AKT-mTOR pathway as a risk factor of central nervous system metastasis in metastatic breast cancer. ". Eur J Cancer. 2017. PMID 29103666.
• "Cap-independent translation ensures mTOR expression and function upon protein synthesis inhibition. ". RNA. 2017. PMID 28821580.
• "Targeting the mTOR pathway in breast cancer. ". Tumour Biol. 2017. PMID 28639903.
• "Host Serine/Threonine Kinases mTOR and Protein Kinase C-α Promote InlB-Mediated Entry of Listeria monocytogenes. ". Infect Immun. 2017. PMID 28461391.
• "The simultaneous inhibition of the mTOR and MAPK pathways with Gnetin-C induces apoptosis in acute myeloid leukemia.". Cancer Lett. 2017. PMID 28456658.