MTHFD1

MTHFD1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1A4I, 1DIA, 1DIB, 1DIG
Dynodwyr
Cyfenwau	MTHFD1, MTHFC, MTHFD, C1-THF-Synthase, methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1, CIMAH
Dynodwyr allanol	OMIM: 172460 HomoloGene: 55940 GeneCards: MTHFD1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • methylenetetrahydrofolate dehydrogenase (NADP+) activity • methylenetetrahydrofolate dehydrogenase (NAD+) activity • ligase activity • methylenetetrahydrofolate dehydrogenase [NAD(P)+ activity] • catalytic activity • oxidoreductase activity • ATP binding • hydrolase activity • GO:0001948, GO:0016582 protein binding • formate-tetrahydrofolate ligase activity • methenyltetrahydrofolate cyclohydrolase activity Cydrannau o'r gell • bilen • mitocondria • extracellular exosome • cytoplasm • cytosol Prosesau biolegol • purine nucleotide biosynthetic process • transsulfuration • neutrophil homeostasis • one-carbon metabolic process • serine family amino acid metabolic process • embryonic neurocranium morphogenesis • tetrahydrofolate interconversion • histidine biosynthetic process • cellular amino acid biosynthetic process • somite development • serine family amino acid biosynthetic process • methionine biosynthetic process • heart development • methionine metabolic process • neural tube closure • folic acid metabolic process • embryonic viscerocranium morphogenesis • metabolaeth • purine nucleobase biosynthetic process • 10-formyltetrahydrofolate biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4522	n/a
Ensembl	n/a	n/a
UniProt	P11586	n/a
RefSeq (mRNA)	NM_005956 NM_001364837	n/a
RefSeq (protein)	NP_005947 NP_001351766	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MTHFD1 yw MTHFD1 a elwir hefyd yn C-1-tetrahydrofolate synthase, cytoplasmic a Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MTHFD1.

• CIMAH
• MTHFC
• MTHFD

Llyfryddiaeth

• "One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation. ". PLoS One. 2017. PMID 28968444.
• "Methylenetetrahydrofolate Dehydrogenase 1 Polymorphisms Modify the Associations of Plasma Glycine and Serine With Risk of Acute Myocardial Infarction in Patients With Stable Angina Pectoris in WENBIT (Western Norway B Vitamin Intervention Trial). ". Circ Cardiovasc Genet. 2016. PMID 27872106.
• "MTHFD1 regulates nuclear de novo thymidylate biosynthesis and genome stability. ". Biochimie. 2016. PMID 26853819.
• "B vitamin treatments modify the risk of myocardial infarction associated with a MTHFD1 polymorphism in patients with stable angina pectoris. ". Nutr Metab Cardiovasc Dis. 2016. PMID 26803590.
• "Paternal transmission of MTHFD1 G1958A variant predisposes to neural tube defects in the offspring.". Dev Med Child Neurol. 2016. PMID 26394717.