MPG

MPG
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BNK, 1EWN, 1F4R, 1F6O, 3QI5, 3UBY
Dynodwyr
Cyfenwau	MPG, AAG, ADPG, APNG, CRA36.1, MDG, Mid1, PIG11, PIG16, anpg, N-methylpurine DNA glycosylase
Dynodwyr allanol	OMIM: 156565 HomoloGene: 1824 GeneCards: MPG
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA-7-methylguanine glycosylase activity • DNA-7-methyladenine glycosylase activity • damaged DNA binding • DNA binding • alkylbase DNA N-glycosylase activity • GO:0001948, GO:0016582 protein binding • DNA-3-methylguanine glycosylase activity • catalytic activity • hydrolase activity • DNA-3-methyladenine glycosylase activity • DNA N-glycosylase activity Cydrannau o'r gell • cytoplasm • mitochondrial nucleoid • mitocondria • cnewyllyn cell • nucleoplasm Prosesau biolegol • depurination • DNA dealkylation involved in DNA repair • base-excision repair • cellular response to DNA damage stimulus • GO:0100026 DNA repair Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4350	n/a
Ensembl	ENSG00000103152	n/a
UniProt	P29372	n/a
RefSeq (mRNA)	NM_002434 NM_001015052 NM_001015054	n/a
RefSeq (protein)	NP_001015052 NP_001015054 NP_002425	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MPG yw MPG a elwir hefyd yn N-methylpurine DNA glycosylase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16p13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MPG.

• AAG
• MDG
• ADPG
• APNG
• Mid1
• anpg
• PIG11
• PIG16
• CRA36.1

Llyfryddiaeth

• "Search for DNA damage by human alkyladenine DNA glycosylase involves early intercalation by an aromatic residue. ". J Biol Chem. 2017. PMID 28747435.
• "APNG as a prognostic marker in patients with glioblastoma. ". PLoS One. 2017. PMID 28662073.
• "Effect of MPG gene rs2858056 polymorphism, copy number variation, and level of serum MPG protein on the risk for rheumatoid arthritis. ". PLoS One. 2015. PMID 25757089.
• "Germ line variants of human N-methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N6-ethenoadenine-induced mutations. ". J Biol Chem. 2015. PMID 25538240.
• "Enzymatic MPG DNA repair assays for two different oxidative DNA lesions reveal associations with increased lung cancer risk.". Carcinogenesis. 2014. PMID 25355292.