MNAT1

MNAT1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1G25
Dynodwyr
Cyfenwau	MNAT1, CAP35, MAT1, RNF66, TFB3, CDK activating kinase assembly factor, MNAT1 component of CDK activating kinase
Dynodwyr allanol	OMIM: 602659 HomoloGene: 1821 GeneCards: MNAT1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • ATP-dependent activity, acting on DNA • protein N-terminus binding • metal ion binding • GO:0001948, GO:0016582 protein binding • RNA polymerase II CTD heptapeptide repeat kinase activity • GO:0016534 cyclin-dependent protein serine/threonine kinase activator activity • zinc ion binding Cydrannau o'r gell • nucleoplasm • cnewyllyn cell • cytosol • transcription factor TFIIH holo complex • cyclin-dependent protein kinase activating kinase holoenzyme complex Prosesau biolegol • termination of RNA polymerase I transcription • regulation of cyclin-dependent protein serine/threonine kinase activity • GO:0009373 regulation of transcription, DNA-templated • adult heart development • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • transcription initiation from RNA polymerase I promoter • transcription elongation from RNA polymerase II promoter • negative regulation of apoptotic process • 7-methylguanosine mRNA capping • transcription by RNA polymerase II • ventricular system development • transcription, DNA-templated • response to calcium ion • cell cycle • transcription-coupled nucleotide-excision repair • transcription initiation from RNA polymerase II promoter • cell population proliferation • GO:0100026 DNA repair • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of smooth muscle cell proliferation • protein phosphorylation • nucleotide-excision repair, preincision complex assembly • positive regulation of cyclin-dependent protein serine/threonine kinase activity • nucleotide-excision repair • GO:0034622 protein-containing complex assembly • G1/S transition of mitotic cell cycle • negative regulation of DNA helicase activity • G2/M transition of mitotic cell cycle • GO:0001183 transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4331	n/a
Ensembl	ENSG00000020426	n/a
UniProt	P51948	n/a
RefSeq (mRNA)	NM_001177963 NM_002431	n/a
RefSeq (protein)	NP_001171434 NP_002422	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MNAT1 yw MNAT1 a elwir hefyd yn MNAT1, CDK activating kinase assembly factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q23.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MNAT1.

• MAT1
• TFB3
• CAP35
• RNF66

Llyfryddiaeth

• "The lost intrinsic fragmentation of MAT1 protein during granulopoiesis promotes the growth and metastasis of leukemic myeloblasts. ". Stem Cells. 2013. PMID 23765726.
• "Retinoid-induced G1 arrest and differentiation activation are associated with a switch to cyclin-dependent kinase-activating kinase hypophosphorylation of retinoic acid receptor alpha. ". J Biol Chem. 2002. PMID 12213824.
• "MAT1-modulated CAK activity regulates cell cycle G(1) exit. ". Mol Cell Biol. 2001. PMID 11113200.
• "Solution structure of the N-terminal domain of the human TFIIH MAT1 subunit: new insights into the RING finger family. ". J Biol Chem. 2001. PMID 11056162.
• "Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to chromosome bands 5q13.3-q14 and 14q23, respectively.". Genomics. 1998. PMID 9465303.