MMP9

MMP9
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GKC, 1GKD, 1ITV, 1L6J, 2OVX, 2OVZ, 2OW0, 2OW1, 2OW2, 4H1Q, 4H2E, 4H3X, 4H82, 4HMA, 4JIJ, 4JQG, 4WZV, 4XCT, 5CUH, 5I12
Dynodwyr
Cyfenwau	MMP9, CLG4B, GELB, MANDP2, MMP-9, 92 kDa type IV collagenase, 92 kDa gelatinase, gelatinase B, matrix metallopeptidase 9
Dynodwyr allanol	OMIM: 120361 HomoloGene: 3659 GeneCards: MMP9
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • collagen binding • zinc ion binding • metal ion binding • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • identical protein binding • hydrolase activity • metallopeptidase activity • endopeptidase activity • serine-type endopeptidase activity • metalloendopeptidase activity Cydrannau o'r gell • GO:0005578 extracellular matrix • extracellular exosome • extracellular space • tertiary granule lumen • ficolin-1-rich granule lumen • extracellular region • collagen-containing extracellular matrix Prosesau biolegol • skeletal system development • negative regulation of cation channel activity • positive regulation of protein phosphorylation • endodermal cell differentiation • negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • ossification • negative regulation of intrinsic apoptotic signaling pathway • ephrin receptor signaling pathway • extracellular matrix disassembly • negative regulation of apoptotic process • proteolysis • macrophage differentiation • positive regulation of keratinocyte migration • positive regulation of apoptotic process • collagen catabolic process • positive regulation of release of cytochrome c from mitochondria • positive regulation of receptor binding • positive regulation of DNA binding • positive regulation of epidermal growth factor receptor signaling pathway • embryo implantation • leukocyte migration • positive regulation of vascular associated smooth muscle cell proliferation • extracellular matrix organization • positive regulation of cell migration • neutrophil degranulation • GO:0072353 cellular response to reactive oxygen species • cellular response to cadmium ion • cytokine-mediated signaling pathway • regulation of neuroinflammatory response • negative regulation of epithelial cell differentiation involved in kidney development • response to amyloid-beta Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4318	n/a
Ensembl	ENSG00000100985	n/a
UniProt	P14780	n/a
RefSeq (mRNA)	NM_004994	n/a
RefSeq (protein)	NP_004985	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MMP9 yw MMP9 a elwir hefyd yn Matrix metallopeptidase 9 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20q13.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MMP9.

• GELB
• CLG4B
• MMP-9
• MANDP2

Llyfryddiaeth

• "Crosstalk Between Histone and DNA Methylation in Regulation of Retinal Matrix Metalloproteinase-9 in Diabetes. ". Invest Ophthalmol Vis Sci. 2017. PMID 29261844.
• "MMP9 gene expression regulation by intragenic epigenetic modifications in breast cancer. ". Gene. 2018. PMID 29162512.
• "Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation. ". J Biol Chem. 2017. PMID 28860188.
• "[The plasma levels and diagnostic utility of matrix metalloproteinase-9 and CA 125 in cervical cancer patients]. ". Pol Merkur Lekarski. 2017. PMID 28805195.
• "Serum matrix metalloproteinase-9 levels and prognosis of acute ischemic stroke.". Neurology. 2017. PMID 28747453.