MMP16

MMP16
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1RM8
Dynodwyr
Cyfenwau	MMP16, C8orf57, MMP-X2, MT-MMP2, MT-MMP3, MT3-MMP, matrix metallopeptidase 16
Dynodwyr allanol	OMIM: 602262 HomoloGene: 55939 GeneCards: MMP16
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • GO:0070122 peptidase activity • GO:0010577 enzyme activator activity • hydrolase activity • metallopeptidase activity • metalloendopeptidase activity • zinc ion binding • metalloaminopeptidase activity Cydrannau o'r gell • integral component of membrane • bilen • GO:0005578 extracellular matrix • Cellbilen • extracellular region • cell surface • Golgi lumen • integral component of plasma membrane • extracellular space Prosesau biolegol • ossification • extracellular matrix disassembly • endochondral ossification • craniofacial suture morphogenesis • chondrocyte proliferation • collagen catabolic process • embryonic cranial skeleton morphogenesis • bone development • GO:0048554 positive regulation of catalytic activity • proteolysis • protein processing • GO:0044267 protein metabolic process • skeletal system development • extracellular matrix organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4325	n/a
Ensembl	ENSG00000156103	n/a
UniProt	P51512	n/a
RefSeq (mRNA)	NM_005941 NM_022564 NM_032297	n/a
RefSeq (protein)	NP_005932	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MMP16 yw MMP16 a elwir hefyd yn Matrix metalloproteinase-16 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8q21.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MMP16.

• MMP-X2
• C8orf57
• MT-MMP2
• MT-MMP3
• MT3-MMP

Llyfryddiaeth

• "MT3-MMP down-regulation promotes tumorigenesis and correlates to poor prognosis in esophageal squamous cell carcinoma. ". Cancer Med. 2016. PMID 27292876.
• "Promoter hypermethylation of membrane type 3 matrix metalloproteinase is associated with cell migration in colorectal adenocarcinoma. ". Cancer Genet. 2015. PMID 26002729.
• "MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma. ". Cancer Res. 2015. PMID 25808867.
• "A role for matrix remodelling proteins in invasive and malignant meningiomas. ". Neuropathol Appl Neurobiol. 2015. PMID 24989599.
• "Membrane-type-3 matrix metalloproteinase (MT3-MMP) functions as a matrix composition-dependent effector of melanoma cell invasion.". PLoS One. 2011. PMID 22164270.