MMP12

MMP12
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JIZ, 1JK3, 1OS2, 1OS9, 1RMZ, 1ROS, 1UTT, 1UTZ, 1Y93, 1YCM, 1Z3J, 2HU6, 2JXY, 2K2G, 2K9C, 2KRJ, 2MLR, 2MLS, 2OXU, 2OXW, 2OXZ, 2POJ, 2W0D, 2WO8, 2WO9, 2WOA, 2Z2D, 3BA0, 3EHX, 3EHY, 3F15, 3F16, 3F17, 3F18, 3F19, 3F1A, 3LIK, 3LIL, 3LIR, 3LJG, 3LK8, 3LKA, 3N2U, 3N2V, 3NX7, 3RTS, 3RTT, 3TS4, 3TSK, 3UVC, 4EFS, 4GQL, 4GR0, 4GR3, 4GR8, 4GUY, 4H30, 4H49, 4H76, 4H84, 4I03, 4IJO, 2N8R, 5I4O, 5I0L, 5I2Z, 5I3M, 5I43
Dynodwyr
Cyfenwau	MMP12, HME, ME, MME, MMP-12, Matrix metallopeptidase 12
Dynodwyr allanol	OMIM: 601046 HomoloGene: 20547 GeneCards: MMP12
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0070122 peptidase activity • endopeptidase activity • hydrolase activity • metallopeptidase activity • metal ion binding • serine-type endopeptidase activity • metalloendopeptidase activity • calcium ion binding • collagen binding • zinc ion binding • sequence-specific DNA binding Cydrannau o'r gell • GO:0005578 extracellular matrix • extracellular region • extracellular space • cnewyllyn cell • cytoplasm Prosesau biolegol • collagen catabolic process • wound healing, spreading of epidermal cells • extracellular matrix disassembly • positive regulation of epithelial cell proliferation involved in wound healing • wound healing • GO:1901227 negative regulation of transcription by RNA polymerase II • proteolysis • protein import into nucleus • GO:1901313 positive regulation of gene expression • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of defense response to virus by host • negative regulation of type I interferon-mediated signaling pathway • positive regulation of type I interferon-mediated signaling pathway • cellular response to virus • response to hypoxia • elastin catabolic process • negative regulation of endothelial cell-matrix adhesion via fibronectin • extracellular matrix organization • response to amyloid-beta Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4321	n/a
Ensembl	ENSG00000262406	n/a
UniProt	P39900	n/a
RefSeq (mRNA)	NM_002426	n/a
RefSeq (protein)	NP_002417	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MMP12 yw MMP12 a elwir hefyd yn Matrix metallopeptidase 12 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q22.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MMP12.

• ME
• HME
• MME
• MMP-12

Llyfryddiaeth

• "The G allele of MMP12 -82 A > G promoter polymorphism as a protective factor for COPD in Bulgarian population. ". Arch Physiol Biochem. 2017. PMID 28692348.
• "Matrix metalloproteinase-12 expression is increased in cutaneous melanoma and associated with tumor aggressiveness. ". Tumour Biol. 2015. PMID 26040769.
• "A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach. ". PLoS Genet. 2014. PMID 25078452.
• "MMP-12 as a new marker of Stanford-A acute aortic dissection. ". Ann Med. 2014. PMID 24432723.
• "[Research progress of matrix metalloproteinase 12 in non-small cell lung cancer].". Zhongguo Fei Ai Za Zhi. 2014. PMID 24398311.