MID2

MID2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DJA, 2DMK
Dynodwyr
Cyfenwau	MID2, FXY2, MRX101, RNF60, TRIM1, midline 2, XLID101
Dynodwyr allanol	OMIM: 300204 HomoloGene: 8028 GeneCards: MID2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • microtubule binding • zinc ion binding • metal ion binding • phosphoprotein binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • identical protein binding • transferase activity Cydrannau o'r gell • cytoplasm • intracellular anatomical structure • microtubule • extracellular exosome • Cytosgerbwd Prosesau biolegol • positive regulation of autophagy • positive regulation of DNA-binding transcription factor activity • protein localization to microtubule • positive regulation of NF-kappaB transcription factor activity • protein ubiquitination • positive regulation of I-kappaB kinase/NF-kappaB signaling • innate immune response • negative regulation of viral transcription • negative regulation of viral entry into host cell Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11043	n/a
Ensembl	ENSG00000080561	n/a
UniProt	Q9UJV3	n/a
RefSeq (mRNA)	NM_012216 NM_052817 NM_001382751 NM_001382752	n/a
RefSeq (protein)	NP_036348 NP_438112 NP_001369680 NP_001369681	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MID2 yw MID2 a elwir hefyd yn Midline 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xq22.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MID2.

• FXY2
• RNF60
• TRIM1
• MRX101

Llyfryddiaeth

• "Functional characterization of the Opitz syndrome gene product (midin): evidence for homodimerization and association with microtubules throughout the cell cycle. ". Hum Mol Genet. 1999. PMID 10400985.
• "Trim5alpha protein restricts both HIV-1 and murine leukemia virus. ". Proc Natl Acad Sci U S A. 2004. PMID 15249690.
• "Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cell proliferation in vitro and in vivo. ". Front Med. 2016. PMID 26791755.
• "Targeted deep resequencing identifies MID2 mutation for X-linked intellectual disability with varied disease severity in a large kindred from India. ". Hum Mutat. 2014. PMID 24115387.
• "An Xq22.3 duplication detected by comparative genomic hybridization microarray (Array-CGH) defines a new locus (FGS5) for FG syndrome.". Am J Med Genet A. 2005. PMID 16283679.