MEN1

MEN1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3U84, 3U85, 3U86, 3U88, 4GPQ, 4GQ3, 4GQ4, 4I80, 4OG3, 4OG4, 4OG5, 4OG6, 4OG7, 4OG8, 4X5Y, 4X5Z, 5DDF, 5DD9, 5DDA, 5DDE, 5DDB, 5DDD, 5DDC, 5DB0, 5DB3, 5DB1, 5DB2
Dynodwyr
Cyfenwau	MEN1, MEAI, SCG2, menin 1
Dynodwyr allanol	OMIM: 613733 HomoloGene: 7418 GeneCards: MEN1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • protein-macromolecule adaptor activity • R-SMAD binding • protein N-terminus binding • chromatin binding • histone-lysine N-methyltransferase activity • GO:0001948, GO:0016582 protein binding • four-way junction DNA binding • Y-form DNA binding • double-stranded DNA binding Cydrannau o'r gell • cytoplasm • cytosol • nuclear matrix • nucleoplasm • chromatin • cleavage furrow • cnewyllyn cell • histone methyltransferase complex • endoplasmic reticulum lumen • GO:0009327 protein-containing complex Prosesau biolegol • negative regulation of cell-substrate adhesion • GO:0033128 negative regulation of protein phosphorylation • positive regulation of transforming growth factor beta receptor signaling pathway • GO:0009373 regulation of transcription, DNA-templated • negative regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of telomerase activity • negative regulation of cell cycle • regulation of activin receptor signaling pathway • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of DNA-binding transcription factor activity • negative regulation of osteoblast differentiation • negative regulation of cell cycle G1/S phase transition • MAPK cascade • cellular response to DNA damage stimulus • negative regulation of JNK cascade • brain development • cellular response to peptide hormone stimulus • decidualization • negative regulation of epithelial cell proliferation • GO:0007067 Mitosis • osteoblast development • positive regulation of protein binding • GO:0045996 negative regulation of transcription, DNA-templated • response to gamma radiation • response to UV • type B pancreatic cell differentiation • GO:0100026 DNA repair • regulation of type B pancreatic cell proliferation • cellular response to glucose stimulus • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of cell population proliferation • response to transforming growth factor beta • histone lysine methylation • beta-catenin-TCF complex assembly • transcription, DNA-templated • post-translational protein modification • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4221	n/a
Ensembl	ENSG00000133895	n/a
UniProt	O00255	n/a
RefSeq (mRNA)	NM_000244 NM_130799 NM_130800 NM_130801 NM_130802 NM_130803 NM_130804 NM_001370251 NM_001370259 NM_001370260 NM_001370261 NM_001370262 NM_001370263	n/a
RefSeq (protein)	NP_000235 NP_570711 NP_570712 NP_570713 NP_570714 NP_570715 NP_570716 NP_001357180 NP_001357188 NP_001357189 NP_001357190 NP_001357191 NP_001357192	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MEN1 yw MEN1 a elwir hefyd yn Menin 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MEN1.

• MEAI
• SCG2

Llyfryddiaeth

• "Enhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer. ". Cell Rep. 2017. PMID 28273452.
• "Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis. ". Hum Pathol. 2016. PMID 27342911.
• "Multiple endocrine neoplasia type 1 associated with a new germline Men1 mutation in a family with atypical tumor phenotype. ". Hormones (Athens). 2016. PMID 26732163.
• "Menin localization in cell membrane compartment. ". Cancer Biol Ther. 2016. PMID 26560942.
• "Novel MEN 1 gene findings in rare sporadic insulinoma--a case control study.". BMC Endocr Disord. 2015. PMID 26307114.