MED1 Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1RJK , 1RK3 , 1RKG , 1RKH , 2O4J , 2O4R , 2ZFX , 3A2H , 3AUN , 3VJS , 3VJT , 3VRT , 3VRU , 3VRV , 3VRW , 3W0G , 3W0H , 3W0I , 3W0J , 3W5P , 3W5Q , 3W5R , 3W5T , 3WT5 , 3WT6 , 3WT7 , 3WTQ , 5AWK , 5AWJ , 4YNK , 5B5B
Dynodwyr Cyfenwau MED1 Dynodwyr allanol OMIM: 604311 HomoloGene: 21002 GeneCards: MED1 Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0032403 protein-containing complex binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • estrogen receptor binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • transcription factor binding • GO:0001104 transcription coregulator activity • thyroid hormone receptor binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • retinoic acid receptor binding • chromatin binding • LBD domain binding • GO:0001948, GO:0016582 protein binding • nuclear receptor binding • vitamin D receptor binding • DNA binding • mediator complex binding • GO:0001105 transcription coactivator activity • peroxisome proliferator activated receptor binding • nuclear receptor coactivator activity • chromatin DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • GO:0001106 transcription corepressor activity • signaling receptor activity Cydrannau o'r gell • bilen • cnewyllyn cell • mediator complex • nucleolus • chromatin • ubiquitin ligase complex • nucleoplasm • protein-DNA complex Prosesau biolegol • regulation of RNA biosynthetic process • thyroid hormone mediated signaling pathway • negative regulation of neuron differentiation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • monocyte differentiation • embryonic heart tube development • androgen biosynthetic process • epithelial cell proliferation involved in mammary gland duct elongation • enucleate erythrocyte development • animal organ regeneration • angiogenesis • animal organ morphogenesis • GO:0009373 regulation of transcription, DNA-templated • negative regulation of keratinocyte proliferation • positive regulation of erythrocyte differentiation • regulation of transcription by RNA polymerase I • ERK1 and ERK2 cascade • in utero embryonic development • mammary gland branching involved in pregnancy • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • heart development • protein ubiquitination • camera-type eye development • transcription initiation from RNA polymerase II promoter • lactation • cellular response to steroid hormone stimulus • positive regulation of intracellular estrogen receptor signaling pathway • peroxisome proliferator activated receptor signaling pathway • cellular response to hepatocyte growth factor stimulus • positive regulation of keratinocyte differentiation • positive regulation of interferon-gamma-mediated signaling pathway • positive regulation of G0 to G1 transition • embryonic placenta development • negative regulation of apoptotic process • intracellular steroid hormone receptor signaling pathway • GO:1901227 negative regulation of transcription by RNA polymerase II • retinal pigment epithelium development • ventricular trabecula myocardium morphogenesis • thyroid hormone generation • fat cell differentiation • positive regulation of hepatocyte proliferation • megakaryocyte development • androgen receptor signaling pathway • positive regulation of mammary gland epithelial cell proliferation • mammary gland epithelial cell proliferation • mammary gland branching involved in thelarche • regulation of vitamin D receptor signaling pathway • mRNA transcription by RNA polymerase II • keratinocyte differentiation • regulation of cell cycle • cellular response to epidermal growth factor stimulus • multicellular organism development • positive regulation of signaling receptor activity • brain development • GO:1901313 positive regulation of gene expression • lens development in camera-type eye • GO:0000767 cell morphogenesis • embryonic hemopoiesis • cellular response to thyroid hormone stimulus • positive regulation of cell population proliferation • liver development • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • erythrocyte development • embryonic hindlimb morphogenesis • regulation of lipid metabolic process • protein import into nucleus Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn MED1 yw MED1 a elwir hefyd yn Mediator complex subunit 1 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q12.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MED1.
PBP
CRSP1
RB18A
TRIP2
PPARBP
CRSP200
DRIP205
DRIP230
PPARGBP
TRAP220
"Vitamin D Receptor Fok-I polymorphism modulates diabetic host response to vitamin D intake: need for a nutrigenetic approach. ". Diabetes Care . 2013. PMID 23160722 . "Loss of Med1/TRAP220 promotes the invasion and metastasis of human non-small-cell lung cancer cells by modulating the expression of metastasis-related genes. ". Cancer Lett . 2012. PMID 22342682 . "MED1 mediates androgen receptor splice variant induced gene expression in the absence of ligand. ". Oncotarget . 2015. PMID 25481872 . "Effects of vitamin D receptor polymorphisms on the risk of schizophrenia and metabolic changes caused by risperidone treatment. ". Psychiatry Res . 2014. PMID 24418047 . "Silencing MED1 sensitizes breast cancer cells to pure anti-estrogen fulvestrant in vitro and in vivo. ". PLoS One . 2013. PMID 23936234 . 
