MDM4

MDM4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CR8, 2VJE, 2VJF, 2VYR, 3DAB, 3EQY, 3FDO, 3FE7, 3FEA, 3JZO, 3JZP, 3JZQ, 3LBJ, 3MQR, 3U15, 4RXZ, 2MWY, 2N06, 2N0W, 2N14, 2N0U
Dynodwyr
Cyfenwau	MDM4, HDMX, MDMX, MRP1, p53 regulator, MDM4 regulator of p53, BMFS6
Dynodwyr allanol	OMIM: 602704 HomoloGene: 1794 GeneCards: MDM4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • enzyme binding • GO:0001948, GO:0016582 protein binding • metal ion binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • zinc ion binding Cydrannau o'r gell • cnewyllyn cell • nucleoplasm Prosesau biolegol • G0 to G1 transition • DNA damage response, signal transduction by p53 class mediator • protein stabilization • cell population proliferation • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • cellular response to hypoxia • GO:1903363 negative regulation of protein catabolic process • negative regulation of cell population proliferation • protein ubiquitination • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • regulation of signal transduction by p53 class mediator • protein deubiquitination • GO:0034622 protein-containing complex assembly • heart valve development • atrioventricular valve morphogenesis • endocardial cushion morphogenesis • ventricular septum development • atrial septum development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4194	n/a
Ensembl	ENSG00000198625	n/a
UniProt	O15151 Q5T0Y2	n/a
RefSeq (mRNA)	NM_001204171 NM_001204172 NM_001278516 NM_001278517 NM_001278518 NM_001278519 NM_002393	n/a
RefSeq (protein)	NP_001191100 NP_001191101 NP_001265445 NP_001265446 NP_001265447 NP_001265448 NP_002384	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MDM4 yw MDM4 a elwir hefyd yn Protein Mdm4 a MDM4, p53 regulator (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q32.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MDM4.

• HDMX
• MDMX
• MRP1

Llyfryddiaeth

• "Effect of the Flexible Regions of the Oncoprotein Mouse Double Minute X on Inhibitor Binding Affinity. ". Biochemistry. 2017. PMID 29023092.
• "Optimal Affinity Enhancement by a Conserved Flexible Linker Controls p53 Mimicry in MdmX. ". Biophys J. 2017. PMID 28487147.
• "MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability. ". Mol Cancer. 2017. PMID 28270148.
• "MDM4 genetic variants and risk of gastric cancer in an Eastern Chinese population. ". Oncotarget. 2017. PMID 28099948.
• "The role of MDM4 SNP34091 A>C polymorphism in cancer: a meta-analysis on 19,328 patients and 51,058 controls.". Int J Biol Markers. 2017. PMID 27646776.