MCL1

MCL1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2KBW, 2MHS, 2NL9, 2NLA, 2PQK, 3D7V, 3IO9, 3KJ0, 3KJ1, 3KJ2, 3KZ0, 3MK8, 3PK1, 3TWU, 3WIX, 3WIY, 4BPI, 4BPJ, 4HW2, 4HW3, 4HW4, 4OQ5, 4OQ6, 4WGI, 4WMR, 4WMS, 4WMT, 4WMU, 4WMV, 4WMW, 4WMX, 4ZBF, 4ZBI, 5FDO, 5FDR, 5FC4, 5C3F
Dynodwyr
Cyfenwau	MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT, myeloid cell leukemia 1, BCL2 family apoptosis regulator, BCL2 family apoptosis regulator, MCL1 apoptosis regulator, BCL2 family member
Dynodwyr allanol	OMIM: 159552 HomoloGene: 7413 GeneCards: MCL1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • BH3 domain binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • protein homodimerization activity • protein transmembrane transporter activity Cydrannau o'r gell • cytoplasm • integral component of membrane • bilen • Bcl-2 family protein complex • nucleoplasm • mitochondrial outer membrane • mitochondrial matrix • mitocondria • cnewyllyn cell • cytosol Prosesau biolegol • regulation of apoptotic process • cell differentiation • response to cytokine • cellular homeostasis • multicellular organism development • positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway • apoptotic mitochondrial changes • extrinsic apoptotic signaling pathway in absence of ligand • cell fate determination • regulation of response to DNA damage stimulus • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of anoikis • GO:0097285 apoptotic process • negative regulation of apoptotic process • protein transmembrane transport • negative regulation of autophagy • intrinsic apoptotic signaling pathway in response to DNA damage • negative regulation of intrinsic apoptotic signaling pathway • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4170	n/a
Ensembl	ENSG00000143384	n/a
UniProt	Q07820	n/a
RefSeq (mRNA)	NM_182763 NM_001197320 NM_021960	n/a
RefSeq (protein)	NP_001184249 NP_068779 NP_877495	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MCL1 yw MCL1 a elwir hefyd yn MCL1, BCL2 family apoptosis regulator (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q21.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MCL1.

• TM
• EAT
• MCL1L
• MCL1S
• Mcl-1
• BCL2L3
• MCL1-ES
• bcl2-L-3
• mcl1/EAT

Llyfryddiaeth

• "Inhibition of Mcl-1 enhances Pevonedistat-triggered apoptosis in osteosarcoma cells. ". Exp Cell Res. 2017. PMID 28663057.
• "Angiotensin II degrades myeloid cell leukemia 1 in human umbilical vein endothelial cells. ". IUBMB Life. 2017. PMID 28261909.
• "Thioridazine enhances sensitivity to carboplatin in human head and neck cancer cells through downregulation of c-FLIP and Mcl-1 expression. ". Cell Death Dis. 2017. PMID 28182008.
• "Bone marrow microenvironment-derived signals induce Mcl-1 dependence in multiple myeloma. ". Blood. 2017. PMID 28151428.
• "Toxoplasma gondii induces autophagy and apoptosis in human umbilical cord mesenchymal stem cells via downregulation of Mcl-1.". Cell Cycle. 2017. PMID 28112581.