MCF2L

MCF2L
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1KZ7, 1KZG, 1LB1, 1RJ2
Dynodwyr
Cyfenwau	MCF2L, ARHGEF14, DBS, OST, MCF.2 cell line derived transforming sequence like
Dynodwyr allanol	OMIM: 609499 HomoloGene: 11804 GeneCards: MCF2L
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphatidylinositol binding • lipid binding • guanyl-nucleotide exchange factor activity Cydrannau o'r gell • cytoplasm • extrinsic component of cytoplasmic side of plasma membrane • cytosol • Cellbilen • bilen • endomembrane system • extracellular space Prosesau biolegol • positive regulation of Rho protein signal transduction • regulation of Rho protein signal transduction • GO:0007243 intracellular signal transduction • regulation of small GTPase mediated signal transduction • positive regulation of apoptotic process • G protein-coupled receptor signaling pathway • regulation of molecular function Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23263	n/a
Ensembl	ENSG00000126217	n/a
UniProt	O15068	n/a
RefSeq (mRNA)	NM_001112732 NM_024979 NM_001320815 NM_001320816 NM_001320817 NM_001366644 NM_001366645 NM_001366646	n/a
RefSeq (protein)	NP_001106203 NP_001307744 NP_001307745 NP_001307746 NP_079255 NP_001353573 NP_001353574 NP_001353575	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MCF2L yw MCF2L a elwir hefyd yn Guanine nucleotide exchange factor DBS a MCF.2 cell line derived transforming sequence like (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 13, band 13q34.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MCF2L.

• DBS
• OST
• ARHGEF14

Llyfryddiaeth

• "A variant in MCF2L is associated with osteoarthritis. ". Am J Hum Genet. 2011. PMID 21871595.
• "The rho-specific guanine nucleotide exchange factor Dbs regulates breast cancer cell migration. ". J Biol Chem. 2009. PMID 19366686.
• "Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874. ". BMC Med Genet. 2015. PMID 26584642.
• "A rare variant in MCF2L identified using exclusion linkage in a pedigree with premature atherosclerosis. ". Eur J Hum Genet. 2016. PMID 25898923.
• "Regulation of vesicle transport and cell motility by Golgi-localized Dbs.". Small GTPases. 2014. PMID 25483302.