MBP

MBP
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ZGL, 1BX2, 1FV1, 1HQR, 1K2D, 1YMM
Dynodwyr
Cyfenwau	MBP, myelin basic protein
Dynodwyr allanol	OMIM: 159430 HomoloGene: 1788 GeneCards: MBP
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • protease binding • calmodulin binding • structural constituent of myelin sheath Cydrannau o'r gell • cnewyllyn cell • cell projection • bilen • Cellbilen • intracellular anatomical structure • internode region of axon • neuronal cell body • myelin sheath • compact myelin • cyrion cell • cell surface • GO:0009327 protein-containing complex Prosesau biolegol • chemical synaptic transmission • membrane organization • central nervous system development • axon ensheathment • substantia nigra development • response to toxic substance • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • sensory perception of sound • MAPK cascade • negative regulation of heterotypic cell-cell adhesion • maintenance of blood-brain barrier • myelination • positive regulation of metalloendopeptidase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4155	n/a
Ensembl	ENSG00000197971	n/a
UniProt	P02686	n/a
RefSeq (mRNA)	NM_001025081 NM_001025090 NM_001025092 NM_001025094 NM_001025098 NM_001025100 NM_001025101 NM_002385	n/a
RefSeq (protein)	NP_001020252 NP_001020261 NP_001020263 NP_001020271 NP_001020272 NP_002376	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MBP yw MBP a elwir hefyd yn Myelin basic protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 18, band 18q23.

Llyfryddiaeth

• "Variation within MBPgene predicts disease course in multiple sclerosis. ". Brain Behav. 2017. PMID 28413712.
• "Changes of gene expression in T lymphocytes following Golli‑MBP gene RNA interference. ". Mol Med Rep. 2016. PMID 27748888.
• "Isoaspartic acid is present at specific sites in myelin basic protein from multiple sclerosis patients: could this represent a trigger for disease onset?". Acta Neuropathol Commun. 2016. PMID 27519525.
• "Early activation of CD4+ and CD8+ T lymphocytes by myelin basic protein in subjects with MS. ". J Transl Med. 2015. PMID 26526848.
• "MyelStones: the executive roles of myelin basic protein in myelin assembly and destabilization in multiple sclerosis.". Biochem J. 2015. PMID 26518750.