MARS

MARS1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DJV, 4BL7, 4BVX, 4BVY
Dynodwyr
Cyfenwau	MARS1, METRS, MRS, MTRNS, SPG70, CMT2U, ILFS2, ILLD, methionyl-tRNA synthetase, methionyl-tRNA synthetase 1, MARS, TTD9
Dynodwyr allanol	OMIM: 156560 HomoloGene: 90878 GeneCards: MARS1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • aminoacyl-tRNA ligase activity • tRNA binding • nucleotide binding • ligase activity • ATP binding • RNA binding • methionine-tRNA ligase activity Cydrannau o'r gell • extracellular exosome • bilen • nucleolus • cytoplasm • aminoacyl-tRNA synthetase multienzyme complex • cytosol • cnewyllyn cell Prosesau biolegol • protein biosynthesis • tRNA aminoacylation for protein translation • cellular response to starvation • rRNA transcription • cellular response to insulin stimulus • cellular response to platelet-derived growth factor stimulus • cellular response to epidermal growth factor stimulus • positive regulation of transcription of nucleolar large rRNA by RNA polymerase I • methionyl-tRNA aminoacylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4141	n/a
Ensembl	ENSG00000166986	n/a
UniProt	P56192	n/a
RefSeq (mRNA)	NM_004990	n/a
RefSeq (protein)	NP_004981	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MARS yw MARS a elwir hefyd yn Methionine--tRNA ligase, cytoplasmic a Methionyl-tRNA synthetase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MARS.

• MRS
• ILLD
• CMT2U
• ILFS2
• METRS
• MTRNS
• SPG70

Llyfryddiaeth

• "Biallelic Mutations of Methionyl-tRNA Synthetase Cause a Specific Type of Pulmonary Alveolar Proteinosis Prevalent on Réunion Island. ". Am J Hum Genet. 2015. PMID 25913036.
• "Rare recessive loss-of-function methionyl-tRNA synthetase mutations presenting as a multi-organ phenotype. ". BMC Med Genet. 2013. PMID 24103465.
• "Exome sequencing identifies a significant variant in methionyl-tRNA synthetase (MARS) in a family with late-onset CMT2. ". J Neurol Neurosurg Psychiatry. 2013. PMID 23729695.
• "Two non-redundant fragments in the N-terminal peptide of human cytosolic methionyl-tRNA synthetase were indispensable for the multi-synthetase complex incorporation and enzyme activity. ". Biochim Biophys Acta. 2009. PMID 19064003.
• "Methionyl-tRNA synthetase.". Acta Biochim Pol. 2001. PMID 11732605.