MAPT

MAPT
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1I8H, 4GLR, 2ON9, 3OVL, 4E0M, 4E0N, 4E0O, 4FL5, 4NP8, 2MZ7, 4TQE, 4Y5I, 4Y32, 5DMG, 4Y3B, 5HF3, 5E2W, 5E2V
Dynodwyr
Cyfenwau	MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, microtubule associated protein tau, Tau proteins, tau-40
Dynodwyr allanol	OMIM: 157140 HomoloGene: 74962 GeneCards: MAPT
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • apolipoprotein binding • SH3 domain binding • tubulin binding • GO:0001948, GO:0016582 protein binding • lipoprotein particle binding • enzyme binding • DNA binding • actin binding • microtubule binding • dynactin binding • receptor ligand activity • protein phosphatase 2A binding • Hsp90 protein binding • minor groove of adenine-thymine-rich DNA binding • double-stranded DNA binding • single-stranded DNA binding • RNA binding • protein kinase binding • protein-macromolecule adaptor activity • phosphatidylinositol binding • identical protein binding • protein homodimerization activity • sequence-specific DNA binding • chaperone binding • histone-dependent DNA binding • microtubule lateral binding • phosphatidylinositol bisphosphate binding Cydrannau o'r gell • cytoplasm • cell body • cell projection • nuclear periphery • growth cone • neurofibrillary tangle • Cellbilen • tubulin complex • dendrite • cytoplasmic ribonucleoprotein granule • Cytosgerbwd • cnewyllyn cell • cytosol • microtubule • microtubule associated complex • bilen • nuclear speck • axon • somatodendritic compartment • neuronal cell body • axon cytoplasm • extracellular region • intracellular anatomical structure • mitocondria • microtubule cytoskeleton • axolemma • neuron projection • dendritic spine • main axon • membrane raft • glial cell projection Prosesau biolegol • generation of neurons • regulation of autophagy • regulation of microtubule polymerization • positive regulation of microtubule polymerization • positive regulation of axon extension • microtubule cytoskeleton organization • microglial cell activation • activation of cysteine-type endopeptidase activity involved in apoptotic process • GO:0072468 signal transduction • Cof • negative regulation of mitochondrial membrane potential • axonal transport of mitochondrion • cytoplasmic microtubule organization • neuron projection development • positive regulation of superoxide anion generation • negative regulation of kinase activity • cellular response to heat • astrocyte activation • intracellular distribution of mitochondria • synapse organization • regulation of calcium-mediated signaling • protein complex oligomerization • plus-end-directed organelle transport along microtubule • regulation of mitochondrial fission • negative regulation of mitochondrial fission • axonal transport • regulation of cellular response to heat • positive regulation of neuron death • positive regulation of protein localization to synapse • neurofibrillary tangle assembly • negative regulation of establishment of protein localization to mitochondrion • positive regulation of diacylglycerol kinase activity • regulation of response to DNA damage stimulus • internal protein amino acid acetylation • cell-cell signaling • response to lead ion • regulation of signaling receptor activity • negative regulation of gene expression • rRNA metabolic process • central nervous system neuron development • regulation of microtubule polymerization or depolymerization • regulation of chromosome organization • stress granule assembly • GO:0072353 cellular response to reactive oxygen species • microtubule polymerization • regulation of synaptic plasticity • axon development • regulation of microtubule cytoskeleton organization • supramolecular fiber organization • regulation of long-term synaptic depression • positive regulation of protein localization • negative regulation of tubulin deacetylation • amyloid fibril formation • cellular response to nerve growth factor stimulus • cellular response to brain-derived neurotrophic factor stimulus Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4137	n/a
Ensembl	ENSG00000186868 ENSG00000276155 ENSG00000277956	n/a
UniProt	P10636	n/a
RefSeq (mRNA)	NM_001123066 NM_001123067 NM_001203251 NM_001203252 NM_005910 NM_016834 NM_016835 NM_016841 NM_001377265 NM_001377266 NM_001377267 NM_001377268	n/a
RefSeq (protein)	NP_001116538 NP_001116539 NP_001190180 NP_001190181 NP_005901 NP_058518 NP_058519 NP_058525 NP_001364194 NP_001364195 NP_001364196 NP_001364197	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAPT yw MAPT a elwir hefyd yn Microtubule associated protein tau (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q21.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAPT.

• TAU
• MSTD
• PPND
• DDPAC
• MAPTL
• MTBT1
• MTBT2
• FTDP-17
• PPP1R103

Llyfryddiaeth

• "Increased levels of plasma total tau in adult Down syndrome. ". PLoS One. 2017. PMID 29190730.
• "JNK signaling pathway regulates sorbitol-induced Tau proteolysis and apoptosis in SH-SY5Y cells by targeting caspase-3. ". Arch Biochem Biophys. 2017. PMID 29126968.
• "Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons. ". Brain. 2017. PMID 29053786.
• "Dimerization and Long-Range Repulsion Established by Both Termini of the Microtubule-Associated Protein Tau. ". Biochemistry. 2017. PMID 29039655.
• "Isothermal titration calorimetry and vesicle leakage assays highlight the differential behaviors of tau repeat segments upon interaction with anionic lipid membranes.". Biochem Biophys Res Commun. 2017. PMID 28986260.