MAPKAPK2

MAPKAPK2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1KWP, 1NXK, 1NY3, 2JBO, 2JBP, 2OKR, 2ONL, 2OZA, 2P3G, 2PZY, 3A2C, 3FPM, 3FYJ, 3FYK, 3GOK, 3KA0, 3KC3, 3KGA, 3M2W, 3M42, 3R2B, 3R2Y, 3R30, 3WI6, 4TYH
Dynodwyr
Cyfenwau	MAPKAPK2, MAPKAP-K2, MK-2, MK2, mitogen-activated protein kinase-activated protein kinase 2, MAPK activated protein kinase 2
Dynodwyr allanol	OMIM: 602006 HomoloGene: 56412 GeneCards: MAPKAPK2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calmodulin-dependent protein kinase activity • signal transducer activity • nucleotide binding • transferase activity • kinase activity • calcium-dependent protein serine/threonine kinase activity • calmodulin binding • ATP binding • GO:0001948, GO:0016582 protein binding • protein kinase activity • protein serine/threonine kinase activity • mitogen-activated protein kinase binding Cydrannau o'r gell • extracellular exosome • cytosol • centrosome • nucleoplasm • cytoplasm • cnewyllyn cell Prosesau biolegol • response to stress • MAPK cascade • regulation of mRNA stability • response to cytokine • GO:0035404 peptidyl-serine phosphorylation • cellular response to vascular endothelial growth factor stimulus • mRNA stabilization • protein autophosphorylation • 3'-UTR-mediated mRNA stabilization • cellular response to DNA damage stimulus • inner ear development • p38MAPK cascade • Ras protein signal transduction • leukotriene metabolic process • regulation of cellular response to heat • phosphorylation • protein phosphorylation • regulation of interleukin-6 production • vascular endothelial growth factor receptor signaling pathway • response to lipopolysaccharide • inflammatory response • macropinocytosis • regulation of tumor necrosis factor production • toll-like receptor signaling pathway • GO:0007243 intracellular signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9261	n/a
Ensembl	ENSG00000162889	n/a
UniProt	P49137	n/a
RefSeq (mRNA)	NM_004759 NM_032960	n/a
RefSeq (protein)	NP_004750 NP_116584	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAPKAPK2 yw MAPKAPK2 a elwir hefyd yn Mitogen-activated protein kinase-activated protein kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q32.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAPKAPK2.

• MK2
• MK-2
• MAPKAP-K2

Llyfryddiaeth

• "A functional copy-number variation in MAPKAPK2 predicts risk and prognosis of lung cancer. ". Am J Hum Genet. 2012. PMID 22883146.
• "Novel ATP competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series. ". Bioorg Med Chem Lett. 2012. PMID 22119462.
• "Discovery and characterization of MAPK-activated protein kinase-2 prevention of activation inhibitors. ". J Med Chem. 2015. PMID 25255283.
• "The MAPK-activated protein kinase 2 mediates gemcitabine sensitivity in pancreatic cancer cells. ". Cell Cycle. 2014. PMID 24556918.
• "The effect of functional MAPKAPK2 copy number variation CNV-30450 on elevating nasopharyngeal carcinoma risk is modulated by EBV infection.". Carcinogenesis. 2014. PMID 24056810.