MAPK8IP1

MAPK8IP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2G01, 2GMX, 2H96, 3OXI, 3PTG, 3VUD, 3VUG, 3VUH, 3VUI, 3VUK, 3VUL, 3VUM, 4E73, 4G1W, 4H39, 4HYS, 4HYU, 4IZY
Dynodwyr
Cyfenwau	MAPK8IP1, IB1, JIP-1, JIP1, PRKM8IP, mitogen-activated protein kinase 8 interacting protein 1
Dynodwyr allanol	OMIM: 604641 HomoloGene: 31314 GeneCards: MAPK8IP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • MAP-kinase scaffold activity • protein kinase inhibitor activity • GO:0001948, GO:0016582 protein binding • kinesin binding • protein kinase binding • JUN kinase binding • mitogen-activated protein kinase kinase binding • mitogen-activated protein kinase kinase kinase binding Cydrannau o'r gell • cytoplasm • cell body • cytosol • dendritic growth cone • endoplasmic reticulum membrane • mitochondrial membranes • bilen • dentate gyrus mossy fiber • axonal growth cone • synapse • axon • dendrite • Reticwlwm endoplasmig • mitocondria • perinuclear region of cytoplasm • neuron projection • cnewyllyn cell • Cellbilen Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • negative regulation of intrinsic apoptotic signaling pathway • negative regulation of apoptotic process • negative regulation of JNK cascade • regulation of JNK cascade • JUN phosphorylation • negative regulation of JUN kinase activity • vesicle-mediated transport • GO:0072468 signal transduction • positive regulation of MAPK cascade • positive regulation of JNK cascade • regulation of CD8-positive, alpha-beta T cell proliferation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9479	n/a
Ensembl	ENSG00000121653	n/a
UniProt	Q9UQF2	n/a
RefSeq (mRNA)	NM_005456	n/a
RefSeq (protein)	NP_005447	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAPK8IP1 yw MAPK8IP1 a elwir hefyd yn Mitogen-activated protein kinase 8 interacting protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11p11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAPK8IP1.

• IB1
• JIP1
• JIP-1
• PRKM8IP

Llyfryddiaeth

• "JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA). ". Br J Cancer. 2004. PMID 15138488.
• "Calcium- and proteasome-dependent degradation of the JNK scaffold protein islet-brain 1. ". J Biol Chem. 2003. PMID 14507925.
• "Role of the JNK-interacting protein 1/islet brain 1 in cell degeneration in Alzheimer disease and diabetes. ". Brain Res Bull. 2009. PMID 19616077.
• "IB1/JIP-1 controls JNK activation and increased during prostatic LNCaP cells neuroendocrine differentiation. ". Cell Signal. 2005. PMID 15894166.
• "The JNK interacting protein JIP-1 and insulin like growth factor II genes are co-expressed in human embryonic tumours.". Anticancer Res. 2005. PMID 15868948.