MAPK14

MAPK14
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1A9U, 1BL6, 1BL7, 1BMK, 1DI9, 1IAN, 1KV1, 1KV2, 1M7Q, 1OUK, 1OUY, 1OVE, 1OZ1, 1R39, 1R3C, 1W7H, 1W82, 1W83, 1W84, 1WBN, 1WBO, 1WBS, 1WBT, 1WBV, 1WBW, 1WFC, 1YQJ, 1ZYJ, 1ZZ2, 1ZZL, 2BAJ, 2BAK, 2BAL, 2BAQ, 2FSL, 2FSM, 2FSO, 2FST, 2GFS, 2I0H, 2LGC, 2NPQ, 2OKR, 2ONL, 2QD9, 2RG5, 2RG6, 2Y8O, 2YIS, 2YIW, 2YIX, 2ZAZ, 2ZB0, 2ZB1, 3BV2, 3BV3, 3BX5, 3C5U, 3CTQ, 3D7Z, 3D83, 3DS6, 3DT1, 3E92, 3E93, 3FI4, 3FKL, 3FKN, 3FKO, 3FL4, 3FLN, 3FLQ, 3FLS, 3FLW, 3FLY, 3FLZ, 3FMH, 3FMJ, 3FMK, 3FML, 3FMM, 3FMN, 3FSF, 3FSK, 3GC7, 3GCP, 3GCQ, 3GCS, 3GCU, 3GCV, 3GFE, 3GI3, 3HA8, 3HEC, 3HEG, 3HL7, 3HLL, 3HP2, 3HP5, 3HRB, 3HUB, 3HUC, 3HV3, 3HV4, 3HV5, 3HV6, 3HV7, 3HVC, 3IPH, 3ITZ, 3IW5, 3IW6, 3IW7, 3IW8, 3K3I, 3K3J, 3KF7, 3KQ7, 3L8S, 3L8X, 3LFA, 3LFB, 3LFC, 3LFD, 3LFE, 3LFF, 3LHJ, 3MGY, 3MH0, 3MH1, 3MH2, 3MH3, 3MPA, 3MPT, 3MVL, 3MVM, 3MW1, 3NEW, 3NNU, 3NNV, 3NNW, 3NNX, 3NWW, 3O8P, 3O8T, 3O8U, 3OBG, 3OBJ, 3OC1, 3OCG, 3OD6, 3ODY, 3ODZ, 3OEF, 3PG3, 3QUD, 3QUE, 3RIN, 3ROC, 3S3I, 3S4Q, 3U8W, 3UVP, 3UVQ, 3UVR, 3ZS5, 3ZSG, 3ZSH, 3ZSI, 3ZYA, 4A9Y, 4AA0, 4AA4, 4AA5, 4AAC, 4DLI, 4DLJ, 4E5A, 4E5B, 4E6A, 4E6C, 4E8A, 4EH2, 4EH3, 4EH4, 4EH5, 4EH6, 4EH7, 4EH8, 4EH9, 4EHV, 4EWQ, 4F9W, 4F9Y, 4FA2, 4GEO, 4KIN, 4KIP, 4KIQ, 4L8M, 3FC1, 4R3C, 5ETC, 5ETI, 4ZTH
Dynodwyr
Cyfenwau	MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA, mitogen-activated protein kinase 14
Dynodwyr allanol	OMIM: 600289 HomoloGene: 31777 GeneCards: MAPK14
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • kinase activity • protein phosphatase binding • ATP binding • protein kinase activity • MAP kinase activity • protein serine/threonine kinase activity • enzyme binding • NFAT protein binding • transferase activity • GO:0001948, GO:0016582 protein binding • nucleotide binding • MAP kinase kinase activity • mitogen-activated protein kinase p38 binding Cydrannau o'r gell • cytosol • mitocondria • spindle pole • extracellular region • nucleoplasm • nuclear speck • secretory granule lumen • ficolin-1-rich granule lumen • cnewyllyn cell • cytoplasm • glutamatergic synapse Prosesau biolegol • positive regulation of glucose import • positive regulation of muscle cell differentiation • placenta development • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • cellular response to DNA damage stimulus • protein phosphorylation • cell surface receptor signaling pathway • positive regulation of reactive oxygen species metabolic process • positive regulation of cardiac muscle cell proliferation • fatty acid oxidation • angiogenesis • positive regulation of blood vessel endothelial cell migration • glucose metabolic process • cellular response to ionizing radiation • negative regulation of canonical Wnt signaling pathway • GO:0097285 apoptotic process • response to muscle stretch • GO:0009373 regulation of transcription, DNA-templated • positive regulation of erythrocyte differentiation • stress-induced premature senescence • osteoclast differentiation • response to muramyl dipeptide • transcription, DNA-templated • p38MAPK cascade • positive regulation of protein import into nucleus • 3'-UTR-mediated mRNA stabilization • myoblast differentiation involved in skeletal muscle regeneration • chondrocyte differentiation • phosphorylation • signal transduction in response to DNA damage • chemotaxis • positive regulation of myoblast fusion • response to lipopolysaccharide • positive regulation of cyclase activity • cartilage condensation • lipopolysaccharide-mediated signaling pathway • positive regulation of myotube differentiation • GO:0007243 intracellular signal transduction • regulation of cytokine production involved in inflammatory response • DNA damage checkpoint signaling • GO:1901313 positive regulation of gene expression • transmembrane receptor protein serine/threonine kinase signaling pathway • positive regulation of myoblast differentiation • GO:0035404 peptidyl-serine phosphorylation • GO:0000767 cell morphogenesis • striated muscle cell differentiation • cellular response to vascular endothelial growth factor stimulus • cellular response to lipopolysaccharide • positive regulation of brown fat cell differentiation • skeletal muscle tissue development • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0072468 signal transduction • regulation of signal transduction by p53 class mediator • regulation of ossification • neutrophil degranulation • positive regulation of macrophage chemotaxis • positive regulation of metallopeptidase activity • cellular response to lipoteichoic acid • cellular response to tumor necrosis factor • vascular endothelial growth factor receptor signaling pathway • regulation of synaptic membrane adhesion • regulation of gene expression • cellular response to organic substance • Ras protein signal transduction • regulation of DNA-binding transcription factor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1432	n/a
Ensembl	ENSG00000112062	n/a
UniProt	Q16539	n/a
RefSeq (mRNA)	NM_001315 NM_139012 NM_139013 NM_139014	n/a
RefSeq (protein)	NP_001306 NP_620581 NP_620582 NP_620583	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAPK14 yw MAPK14 a elwir hefyd yn Mitogen-activated protein kinase 14 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAPK14.

• RK
• p38
• CSBP
• EXIP
• Mxi2
• CSBP1
• CSBP2
• CSPB1
• PRKM14
• PRKM15
• SAPK2A
• p38ALPHA

Llyfryddiaeth

• "Transforming Growth Factor β/NR4A1-Inducible Breast Cancer Cell Migration and Epithelial-to-Mesenchymal Transition Is p38α (Mitogen-Activated Protein Kinase 14) Dependent. ". Mol Cell Biol. 2017. PMID 28674186.
• "Bauerenol, a triterpenoid from Indian Suregada angustifolia: Induces reactive oxygen species-mediated P38MAPK activation and apoptosis in human hepatocellular carcinoma (HepG2) cells. ". Tumour Biol. 2017. PMID 28443465.
• "Selective p38α MAP kinase/MAPK14 inhibition in enzymatically modified LDL-stimulated human monocytes: implications for atherosclerosis. ". FASEB J. 2017. PMID 27871059.
• "Staphylococcus aureus α-toxin-mediated cation entry depolarizes membrane potential and activates p38 MAP kinase in airway epithelial cells. ". Am J Physiol Lung Cell Mol Physiol. 2016. PMID 27496896.
• "A family-based genome-wide association study reveals an association of spondyloarthritis with MAPK14.". Ann Rheum Dis. 2017. PMID 27461236.