MAPK11

MAPK11
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3GC8, 3GC9, 3GP0
Dynodwyr
Cyfenwau	MAPK11, P38B, P38BETA2, PRKM11, SAPK2, SAPK2B, p38-2, p38Beta, mitogen-activated protein kinase 11
Dynodwyr allanol	OMIM: 602898 HomoloGene: 55684 GeneCards: MAPK11
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • MAP kinase activity • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding Cydrannau o'r gell • cytosol • nucleoplasm • cnewyllyn cell • cytoplasm Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • regulation of cardiac muscle cell proliferation • positive regulation of erythrocyte differentiation • phosphorylation • positive regulation of muscle cell differentiation • transcription, DNA-templated • protein phosphorylation • GO:1901313 positive regulation of gene expression • negative regulation of cardiac muscle cell proliferation • regulation of signal transduction by p53 class mediator • stress-activated MAPK cascade • cellular response to interleukin-1 • regulation of gene expression • GO:0007243 intracellular signal transduction • cellular response to organic substance • Ras protein signal transduction • vascular endothelial growth factor receptor signaling pathway • regulation of DNA-binding transcription factor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5600	n/a
Ensembl	ENSG00000185386	n/a
UniProt	Q15759	n/a
RefSeq (mRNA)	NM_002751	n/a
RefSeq (protein)	NP_002742	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAPK11 yw MAPK11 a elwir hefyd yn Mitogen-activated protein kinase 11 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q13.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAPK11.

• P38B
• SAPK2
• p38-2
• PRKM11
• SAPK2B
• p38Beta
• P38BETA2

Llyfryddiaeth

• "Inhibition of SAPK2/p38 enhances sensitivity to mTORC1 inhibition by blocking IRES-mediated translation initiation in glioblastoma. ". Mol Cancer Ther. 2011. PMID 21911485.
• "Phosphorylation of Raptor by p38beta participates in arsenite-induced mammalian target of rapamycin complex 1 (mTORC1) activation. ". J Biol Chem. 2011. PMID 21757713.
• "MAPK11 in breast cancer cells enhances osteoclastogenesis and bone resorption. ". Biochimie. 2014. PMID 25066918.
• "The p38β mitogen-activated protein kinase possesses an intrinsic autophosphorylation activity, generated by a short region composed of the α-G helix and MAPK insert. ". J Biol Chem. 2014. PMID 25006254.
• "p38β MAP kinase as a therapeutic target for pancreatic cancer.". Chem Biol Drug Des. 2012. PMID 22515544.