MAP4K4

MAP4K4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4OBO, 4OBP, 4OBQ, 4RVT, 4U43, 4U44, 4U45, 4ZK5, 4U42, 5DI1, 4U3Y, 4U3Z, 4U41, 4U40
Dynodwyr
Cyfenwau	MAP4K4, FLH21957, HEL-S-31, HGK, MEKKK4, NIK, mitogen-activated protein kinase kinase kinase kinase 4
Dynodwyr allanol	OMIM: 604666 HomoloGene: 7442 GeneCards: MAP4K4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • creatine kinase activity • protein serine/threonine kinase activity • nucleotide binding • protein kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding • kinase activity • MAP kinase kinase kinase kinase activity • microtubule binding Cydrannau o'r gell • cytoplasm • focal adhesion Prosesau biolegol • protein phosphorylation • regulation of JNK cascade • GO:0007243 intracellular signal transduction • negative regulation of apoptotic process • microvillus assembly • phosphorylation • MAPK cascade • regulation of mitotic cell cycle • neuron projection morphogenesis • negative regulation of neuron projection development • negative regulation of insulin secretion involved in cellular response to glucose stimulus • negative regulation of neuron projection regeneration • negative regulation of cell-matrix adhesion • GO:0072468 signal transduction • positive regulation of cell migration • stress-activated protein kinase signaling cascade • positive regulation of ARF protein signal transduction • activation of protein kinase activity • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • positive regulation of keratinocyte migration • positive regulation of focal adhesion assembly • positive regulation of adherens junction organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9448	n/a
Ensembl	ENSG00000071054	n/a
UniProt	O95819	n/a
RefSeq (mRNA)	NM_001242559 NM_001242560 NM_004834 NM_145686 NM_145687	n/a
RefSeq (protein)	NP_001229488 NP_001229489 NP_004825 NP_663719 NP_663720	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAP4K4 yw MAP4K4 a elwir hefyd yn Mitogen-activated protein kinase kinase kinase kinase 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAP4K4.

• HGK
• NIK
• MEKKK4
• FLH21957
• HEL-S-31

Llyfryddiaeth

• "Epigenetic regulation of HGK/MAP4K4 in T cells of type 2 diabetes patients. ". Oncotarget. 2016. PMID 26918832.
• "Silencing of MAP4K4 by short hairpin RNA suppresses proliferation, induces G1 cell cycle arrest and induces apoptosis in gastric cancer cells. ". Mol Med Rep. 2016. PMID 26549737.
• "MAP4K4 and IL-6+ Th17 cells play important roles in non-obese type 2 diabetes. ". J Biomed Sci. 2017. PMID 28061846.
• "Association of Common Genetic Variants in Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 with Type 2 Diabetes Mellitus in a Chinese Han Population. ". Chin Med J (Engl). 2016. PMID 27174326.
• "MAP4K4 promotes epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma.". Tumour Biol. 2016. PMID 27010469.