MAP3K7

MAP3K7
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2EVA, 2YIY, 4GS6, 4L3P, 4L52, 4L53, 4O91, 5JGD, 5JGA
Dynodwyr
Cyfenwau	MAP3K7, MEKK7, TAK1, TGF1a, mitogen-activated protein kinase kinase kinase 7, FMD2, CSCF
Dynodwyr allanol	OMIM: 602614 HomoloGene: 135715 GeneCards: MAP3K7
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • scaffold protein binding • metal ion binding • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding • magnesium ion binding • MAP kinase kinase kinase activity • identical protein binding • receptor tyrosine kinase binding Cydrannau o'r gell • cytosol • bilen • Cellbilen • endosome membrane • cnewyllyn cell • IkappaB kinase complex • cytoplasm Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • phosphorylation • positive regulation of JUN kinase activity • stimulatory C-type lectin receptor signaling pathway • activation of NF-kappaB-inducing kinase activity • I-kappaB phosphorylation • MyD88-dependent toll-like receptor signaling pathway • transcription, DNA-templated • Fc-epsilon receptor signaling pathway • protein phosphorylation • JNK cascade • positive regulation of T cell activation • positive regulation of NF-kappaB transcription factor activity • positive regulation of interleukin-2 production • positive regulation of T cell cytokine production • histone H3 acetylation • positive regulation of I-kappaB kinase/NF-kappaB signaling • I-kappaB kinase/NF-kappaB signaling • transforming growth factor beta receptor signaling pathway • T cell receptor signaling pathway • nucleotide-binding oligomerization domain containing signaling pathway • GO:0072468 signal transduction • GO:0097285 apoptotic process • Wnt signaling pathway, calcium modulating pathway • stress-activated MAPK cascade • positive regulation of macroautophagy • protein deubiquitination • anoikis • MyD88-independent toll-like receptor signaling pathway • GO:0022415 viral process • interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6885	n/a
Ensembl	ENSG00000135341	n/a
UniProt	O43318	n/a
RefSeq (mRNA)	NM_003188 NM_145331 NM_145332 NM_145333	n/a
RefSeq (protein)	NP_003179 NP_663304 NP_663305 NP_663306	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAP3K7 yw MAP3K7 a elwir hefyd yn Mitogen-activated protein kinase kinase kinase 7 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q15.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAP3K7.

• CSCF
• FMD2
• TAK1
• MEKK7
• TGF1a

Llyfryddiaeth

• "Activation of TAK1 by Chemotactic and Growth Factors, and Its Impact on Human Neutrophil Signaling and Functional Responses. ". J Immunol. 2015. PMID 26491199.
• "TAK1 is a key modulator of the profibrogenic phenotype of human ileal myofibroblasts in Crohn's disease. ". Am J Physiol Gastrointest Liver Physiol. 2015. PMID 26185333.
• "Heterozygous Mutations in MAP3K7, Encoding TGF-β-Activated Kinase 1, Cause Cardiospondylocarpofacial Syndrome. ". Am J Hum Genet. 2016. PMID 27426734.
• "TAK1 is involved in the autophagy process in retinal pigment epithelial cells. ". Biochem Cell Biol. 2016. PMID 26928052.
• "The role of TAK1 expression in thyroid cancer.". Int J Clin Exp Pathol. 2015. PMID 26823762.