MAP3K3

MAP3K3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2C60, 2JRH, 2PPH, 4Y5O, 4YL6, 2O2V
Dynodwyr
Cyfenwau	MAP3K3, MAPKKK3, MEKK3, mitogen-activated protein kinase kinase kinase 3
Dynodwyr allanol	OMIM: 602539 HomoloGene: 69110 GeneCards: MAP3K3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • ATP binding • protein kinase activity • GO:0001948, GO:0016582 protein binding • MAP kinase kinase kinase activity • kinase activity • metal ion binding • nucleotide binding • transferase activity • protein serine/threonine kinase activity Cydrannau o'r gell • cytosol • cytoplasm Prosesau biolegol • GO:0007243 intracellular signal transduction • protein phosphorylation • positive regulation of p38MAPK cascade • protein autophosphorylation • blood vessel development • phosphorylation • positive regulation of I-kappaB kinase/NF-kappaB signaling • regulation of mitotic cell cycle • stress-activated protein kinase signaling cascade • activation of protein kinase activity • regulation of apoptotic process • MAPK cascade • interleukin-1-mediated signaling pathway • positive regulation of cell proliferation in bone marrow • positive regulation of cell migration involved in sprouting angiogenesis • negative regulation of cellular senescence • GO:0072468 signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4215	n/a
Ensembl	ENSG00000198909	n/a
UniProt	Q99759	n/a
RefSeq (mRNA)	NM_002401 NM_203351 NM_001330431 NM_001363768	n/a
RefSeq (protein)	NP_001317360 NP_002392 NP_976226 NP_001350697	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAP3K3 yw MAP3K3 a elwir hefyd yn Mitogen-activated protein kinase kinase kinase 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAP3K3.

• MEKK3
• MAPKKK3

Llyfryddiaeth

• "MAP3K3 overexpression is associated with poor survival in ovarian carcinoma. ". Hum Pathol. 2016. PMID 26997451.
• "MAP3K3 expression in tumor cells and tumor-infiltrating lymphocytes is correlated with favorable patient survival in lung cancer. ". Sci Rep. 2015. PMID 26088427.
• "Structural Insights into the Molecular Recognition between Cerebral Cavernous Malformation 2 and Mitogen-Activated Protein Kinase Kinase Kinase 3. ". Structure. 2015. PMID 25982527.
• "A somatic MAP3K3 mutation is associated with verrucous venous malformation. ". Am J Hum Genet. 2015. PMID 25728774.
• "The expression and role of MEKK3 in renal clear cell carcinoma.". Anat Rec (Hoboken). 2015. PMID 25388155.