MAP3K2

MAP3K2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CU1, 2NPT, 5EX0, 5HQ8
Dynodwyr
Cyfenwau	MAP3K2, MEKK2, MEKK2B, mitogen-activated protein kinase kinase kinase 2
Dynodwyr allanol	OMIM: 609487 HomoloGene: 74576 GeneCards: MAP3K2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • GO:0001948, GO:0016582 protein binding • protein kinase binding • kinase activity • ATP binding • protein serine/threonine kinase activity • transferase activity • MAP kinase kinase kinase activity • metal ion binding • protein kinase activity Cydrannau o'r gell • cnewyllyn cell • nucleoplasm • cytoplasm • cytosol Prosesau biolegol • phosphorylation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • cellular response to mechanical stimulus • protein phosphorylation • regulation of mitotic cell cycle • regulation of apoptotic process • GO:0072468 signal transduction • stress-activated protein kinase signaling cascade • activation of protein kinase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10746	n/a
Ensembl	ENSG00000169967	n/a
UniProt	Q9Y2U5	n/a
RefSeq (mRNA)	NM_006609 NM_001371910 NM_001371911	n/a
RefSeq (protein)	NP_006600 NP_001358839 NP_001358840	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAP3K2 yw MAP3K2 a elwir hefyd yn Mitogen-activated protein kinase kinase kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q14.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAP3K2.

• MEKK2
• MEKK2B

Llyfryddiaeth

• "Imaging mass spectrometry of a specific fragment of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 2 discriminates cancer from uninvolved prostate tissue. ". Clin Cancer Res. 2009. PMID 19690195.
• "Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae. ". Nature. 2005. PMID 16001074.
• "Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets. ". Structure. 2016. PMID 27066749.
• "EBV microRNA BART 18-5p targets MAP3K2 to facilitate persistence in vivo by inhibiting viral replication in B cells. ". Proc Natl Acad Sci U S A. 2014. PMID 25012295.
• "MEKK2 regulates focal adhesion stability and motility in invasive breast cancer cells.". Biochim Biophys Acta. 2014. PMID 24491810.