MAP2K6

MAP2K6
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2Y8O, 3ENM, 3FME, 3VN9
Dynodwyr
Cyfenwau	MAP2K6, MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3, mitogen-activated protein kinase kinase 6
Dynodwyr allanol	OMIM: 601254 HomoloGene: 55686 GeneCards: MAP2K6
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • kinase activity • GO:0001948, GO:0016582 protein binding • protein tyrosine kinase activity • ATP binding • protein kinase binding • protein serine/threonine kinase activity • identical protein binding • MAP kinase kinase activity Cydrannau o'r gell • cytoplasm • nucleoplasm • Cytosgerbwd • cnewyllyn cell • cytosol Prosesau biolegol • positive regulation of protein phosphorylation • GO:0009373 regulation of transcription, DNA-templated • cardiac muscle contraction • phosphorylation • cellular response to sorbitol • positive regulation of nitric-oxide synthase biosynthetic process • ovulation cycle process • transcription, DNA-templated • MAPK cascade • protein phosphorylation • positive regulation of prostaglandin secretion • response to ischemia • DNA damage induced protein phosphorylation • positive regulation of apoptotic process • peptidyl-tyrosine phosphorylation • nucleotide-binding oligomerization domain containing signaling pathway • GO:0072468 signal transduction • GO:0097285 apoptotic process • regulation of mitotic cell cycle • stress-activated protein kinase signaling cascade • activation of protein kinase activity • regulation of apoptotic process • negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5608	n/a
Ensembl	ENSG00000108984	n/a
UniProt	P52564	n/a
RefSeq (mRNA)	NM_002758 NM_031988 NM_001330450	n/a
RefSeq (protein)	NP_001317379 NP_002749	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAP2K6 yw MAP2K6 a elwir hefyd yn Mitogen-activated protein kinase kinase 6, isoform CRA_a a Dual-specificity mitogen-activated protein kinase kinase 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q24.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAP2K6.

• MEK6
• MKK6
• MAPKK6
• PRKMK6
• SAPKK3
• SAPKK-3

Llyfryddiaeth

• "MKK6 increases the melanocyte dendricity through the regulation of Rho family GTPases. ". J Dermatol Sci. 2010. PMID 20869211.
• "[Effect of mitogen-activated protein kinase kinase 6-p38 alpha signal pathway on receptor for advanced glycation end-product expression in alveolar epithelial cells induced by mechanical stretch]. ". Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2009. PMID 19846005.
• "Monocytic cell differentiation from band-stage neutrophils under inflammatory conditions via MKK6 activation. ". Blood. 2014. PMID 25214442.
• "MKK6 is upregulated in human esophageal, stomach, and colon cancers. ". Cancer Invest. 2014. PMID 25019214.
• "Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state.". J Biochem. 2012. PMID 22383536.